Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol RU Kadam, IA Wilson Proceedings of the National Academy of Sciences 114 (2), 206-214, 2017 | 487 | 2017 |
Hepatitis C virus E2 envelope glycoprotein core structure L Kong, E Giang, T Nieusma, RU Kadam, KE Cogburn, Y Hua, X Dai, ... Science 342 (6162), 1090-1094, 2013 | 453 | 2013 |
Design of protein-binding proteins from the target structure alone L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ... Nature 605 (7910), 551-560, 2022 | 334 | 2022 |
Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB EMV Johansson, SA Crusz, E Kolomiets, L Buts, RU Kadam, M Cacciarini, ... Chemistry & biology 15 (12), 1249-1257, 2008 | 288 | 2008 |
A glycopeptide dendrimer inhibitor of the galactose-specific lectin LecA and of Pseudomonas aeruginosa biofilms RU Kadam, M Bergmann, M Hurley, D Garg, M Cacciarini, MA Swiderska, ... Angewandte Chemie (International ed. in English) 50 (45), 10631, 2011 | 199 | 2011 |
Potent peptidic fusion inhibitors of influenza virus RU Kadam, J Juraszek, B Brandenburg, C Buyck, WBG Schepens, ... Science 358 (6362), 496-502, 2017 | 159 | 2017 |
Recent trends in drug-likeness prediction: a comprehensive review of in silico methods R Kadam, N Roy Indian Journal of Pharmaceutical Sciences 69 (5), 609, 2007 | 130 | 2007 |
A small-molecule fusion inhibitor of influenza virus is orally active in mice MJP van Dongen, RU Kadam, J Juraszek, E Lawson, B Brandenburg, ... Science 363 (6431), eaar6221, 2019 | 124 | 2019 |
CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA RU Kadam, D Garg, J Schwartz, R Visini, M Sattler, A Stocker, T Darbre, ... ACS chemical biology 8 (9), 1925-1930, 2013 | 115 | 2013 |
Glycopeptide Dendrimers with High Affinity for the Fucose‐Binding Lectin LecB from Pseudomonas aeruginosa E Kolomiets, MA Swiderska, RU Kadam, EMV Johansson, KE Jaeger, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (4), 562-569, 2009 | 102 | 2009 |
Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen L Kong, DE Lee, RU Kadam, T Liu, E Giang, T Nieusma, F Garces, ... Proceedings of the National Academy of Sciences 113 (45), 12768-12773, 2016 | 89 | 2016 |
Preventing an antigenically disruptive mutation in egg-based H3N2 seasonal influenza vaccines by mutational incompatibility NC Wu, H Lv, AJ Thompson, DC Wu, WWS Ng, RU Kadam, CW Lin, ... Cell host & microbe 25 (6), 836-844. e5, 2019 | 74 | 2019 |
Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin ZVF Wright, NC Wu, RU Kadam, IA Wilson, DW Wolan Bioorganic & medicinal chemistry letters 27 (16), 3744-3748, 2017 | 66 | 2017 |
Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids E Johansson, RU Kadam MedChemComm 2 (5), 418-420, 2011 | 65 | 2011 |
Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314–324 in complex with antibody IGH526 L Kong, RU Kadam, E Giang, TB Ruwona, T Nieusma, JC Culhane, ... Journal of molecular biology 427 (16), 2617-2628, 2015 | 58 | 2015 |
Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini M Stach, N Maillard, RU Kadam MedChemComm 3 (1), 86-89, 2012 | 55 | 2012 |
Structure‐Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA RU Kadam, M Bergmann, D Garg, G Gabrieli, A Stocker, T Darbre, ... Chemistry–A European Journal 19 (50), 17054-17063, 2013 | 49 | 2013 |
An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen Y Yao, RU Kadam, CCD Lee, JL Woehl, NC Wu, X Zhu, S Kitamura, ... Proceedings of the National Academy of Sciences 117 (31), 18431-18438, 2020 | 37 | 2020 |
A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin RU Kadam, IA Wilson Proceedings of the National Academy of Sciences 115 (16), 4240-4245, 2018 | 34 | 2018 |
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target N Tzarum, E Giang, RU Kadam, F Chen, K Nagy, EH Augestad, ... Science advances 6 (30), eabb5642, 2020 | 30 | 2020 |