GM2 gangliosidoses: clinical features, pathophysiological aspects, and current therapies AF Leal, E Benincore-Flórez, D Solano-Galarza, RG Garzón Jaramillo, ... International journal of molecular sciences 21 (17), 6213, 2020 | 79 | 2020 |
Lysosomal storage diseases: current therapies and future alternatives AF Leal, AJ Espejo-Mojica, OF Sánchez, CM Ramírez, LH Reyes, JC Cruz, ... Journal of Molecular Medicine 98 (7), 931-946, 2020 | 51 | 2020 |
Differential anti-proliferative effect on K562 leukemia cells of Lippia alba (Verbenaceae) essential oils produced under diverse growing, collection and extraction conditions LT García, AF Leal, ÉM Moreno, EE Stashenko, HJ Arteaga Industrial crops and products 96, 140-148, 2017 | 35 | 2017 |
Tuberculosis por Mycobacterium bovis en trabajadores de fincas en saneamiento para tuberculosis bovina, de Antioquia, Boyacá y Cundinamarca AF Leal-Bohórquez, CM Castro-Osorio, LM Wintaco-Martínez, ... Revista de Salud Pública 18, 727-737, 2016 | 24 | 2016 |
Mucopolysaccharidoses: cellular consequences of glycosaminoglycans accumulation and potential targets AF Leal, E Benincore-Flórez, E Rintz, AM Herreño-Pachón, B Celik, Y Ago, ... International Journal of Molecular Sciences 24 (1), 477, 2022 | 17 | 2022 |
Regulation of molecular targets in osteosarcoma treatment B Celik, K Cicek, AF Leal, S Tomatsu International Journal of Molecular Sciences 23 (20), 12583, 2022 | 14 | 2022 |
Efficient CRISPR/Cas9 nickase-mediated genome editing in an in vitro model of mucopolysaccharidosis IVA AF Leal, CJ Alméciga-Díaz Gene Therapy 30 (1), 107-114, 2023 | 13 | 2023 |
The landscape of CRISPR/Cas9 for inborn errors of metabolism AF Leal, N Fnu, E Benincore-Flórez, AM Herreño-Pachón, ... Molecular genetics and metabolism 138 (1), 106968, 2023 | 8 | 2023 |
Delivery and assessment of a CRISPR/nCas9-based genome editing system on in vitro models of mucopolysaccharidoses IVA assisted by magnetite-based nanoparticles AF Leal, J Cifuentes, CE Torres, D Suárez, V Quezada, SC Gómez, ... Scientific Reports 12 (1), 15045, 2022 | 8 | 2022 |
CRISPR/nCas9-Based genome editing on GM2 gangliosidoses fibroblasts via non-viral vectors AF Leal, J Cifuentes, V Quezada, E Benincore-Flórez, JC Cruz, LH Reyes, ... International Journal of Molecular Sciences 23 (18), 10672, 2022 | 6 | 2022 |
Sphingolipids and their role in health and disease in the central nervous system AF Leal, DA Suarez, OY Echeverri-Peña, SL Albarracín, ... Advances in Biological Regulation 85, 100900, 2022 | 6 | 2022 |
Hematological findings in lysosomal storage disorders: a perspective from the medical laboratory AF Leal, WG Nieto, E Candelo, H Pachajoa, CJ Alméciga-Díaz EJIFCC 33 (1), 28, 2022 | 4 | 2022 |
Iron oxide-coupled CRISPR-nCas9-based genome editing assessment in mucopolysaccharidosis IVA mice AF Leal, B Celik, N Fnu, S Khan, S Tomatsu, CJ Alméciga-Díaz Molecular Therapy-Methods & Clinical Development 31, 2023 | 3 | 2023 |
Recombinant hexosaminidases conjugated to magnetite nanoparticles: Alternative therapeutic treatment routes in GM2 fibroblasts Z Pulido, J Cifuentes, E Benincore, R Garzon, MC Castellanos, A Leal, ... Molecular Genetics and Metabolism 129 (2), S132-S133, 2020 | 2 | 2020 |
Tuberculosis caused by Mycobacterium bovis in workers of bovine tuberculosis sanitation farms in Antioquia, Boyacá and Cundinamarca AF Leal-Bohórquez, CM Castro-Osorio, LM Wintaco-Martínez, ... Revista de Salud Pública 18 (5), 727-737, 2016 | 2 | 2016 |
Current Strategies for Increasing Knock-In Efficiency in CRISPR/Cas9-Based Approaches AF Leal, AM Herreno-Pachón, E Benincore-Flórez, A Karunathilaka, ... International Journal of Molecular Sciences 25 (5), 2456, 2024 | 1 | 2024 |
In vitro evaluation of hydrolytic activity of two recombinant N-acetylglucosaminidases as potential therapeutic tools for mucopolysaccharidosis type IIIB VM Duarte, SS Tibavija, HYT Rojase, AF Leal, S Zamora-Moreno, ... Molecular Genetics and Metabolism 138 (2), 107087, 2023 | 1 | 2023 |
Evaluation of CRISPR/nCas9 for gene editing on mucopolysaccharidosis type IIIB PL Gómez, ENL Rojas, AF Leal, L Diaz, L Perez, AJ Espejo, ... Molecular Genetics and Metabolism 138 (2), 107199, 2023 | 1 | 2023 |
Genome editing on GM2 gangliosidoses fibroblasts using CRISPR/nCas9 AF Leal, AJ Espejo-Mojica, CJ Almeciga-Diaz Molecular Genetics and Metabolism 135 (2), S72, 2022 | 1 | 2022 |
CRISPR/Cas9-based gene therapy for Tay-Sachs disease: Evaluation of non-viral vectors JM Guerrero, AF Leal, AJ Espejo, CJ Alméciga-Díaz Molecular Genetics and Metabolism 141 (2), 107864, 2024 | | 2024 |