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Anthony J O'Donoghue
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Year
Global landscape of HIV–human protein complexes
S Jaeger, P Cimermancic, N Gulbahce, JR Johnson, KE McGovern, ...
Nature 481 (7381), 365-370, 2012
7912012
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
H Li, AJ O’Donoghue, WA Van Der Linden, SC Xie, E Yoo, IT Foe, L Tilley, ...
Nature 530 (7589), 233-236, 2016
2522016
Global identification of peptidase specificity by multiplex substrate profiling
AJ O'Donoghue, AA Eroy-Reveles, GM Knudsen, J Ingram, M Zhou, ...
Nature Methods 9 (11), 1095-1100, 2012
1882012
Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase
AJ O’Donoghue, Y Jin, GM Knudsen, NC Perera, DE Jenne, JE Murphy, ...
PloS one 8 (9), e75141, 2013
1522013
IL-1β is an innate immune sensor of microbial proteolysis
CN LaRock, J Todd, DL LaRock, J Olson, AJ O’Donoghue, ...
Science Immunology 1 (2), eaah3539-eaah3539, 2016
1432016
A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding
G Wendt, L Zhao, R Chen, C Liu, AJ O’Donoghue, CR Caffrey, ML Reese, ...
Science 369 (6511), 1644-1649, 2020
1322020
Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation
H Li, BN Goh, WK Teh, Z Jiang, JPZ Goh, A Goh, G Wu, SS Hoon, ...
Journal of Investigative Dermatology 138 (5), 1137-1145, 2018
1262018
Cloning and characterization of osteoclast precursors from the RAW264. 7 cell line
BLV Cuetara, TN Crotti, AJ O'Donoghue, KP Mchugh
In Vitro Cellular & Developmental Biology-Animal 42, 182-188, 2006
1242006
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
O Julien, M Zhuang, AP Wiita, AJ O’Donoghue, GM Knudsen, CS Craik, ...
Proceedings of the National Academy of Sciences 113 (14), E2001-E2010, 2016
1202016
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
V Hook, M Yoon, C Mosier, G Ito, S Podvin, BP Head, R Rissman, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1868 (8), 140428, 2020
1082020
A parasite cysteine protease is key to host protein degradation and iron acquisition∗
TC O'Brien, ZB Mackey, RD Fetter, Y Choe, AJ O'Donoghue, M Zhou, ...
Journal of Biological Chemistry 283 (43), 28934-28943, 2008
1002008
A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
DM Mellott, CT Tseng, A Drelich, P Fajtová, BC Chenna, DH Kostomiris, ...
ACS chemical biology 16 (4), 642-650, 2021
982021
Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome
AJ O’Donoghue, GM Knudsen, C Beekman, JA Perry, AD Johnson, ...
Proceedings of the National Academy of Sciences 112 (24), 7478-7483, 2015
872015
Immunoproteasome functions explained by divergence in cleavage specificity and regulation
MB Winter, F La Greca, S Arastu-Kapur, F Caiazza, P Cimermancic, ...
Elife 6, e27364, 2017
862017
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
GM LaMonte, J Almaliti, B Bibo-Verdugo, L Keller, BY Zou, J Yang, ...
Journal of medicinal chemistry 60 (15), 6721-6732, 2017
832017
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
M Mahoney, VC Damalanka, MA Tartell, DH Chung, AL Lourenço, ...
Proceedings of the National Academy of Sciences 118 (43), e2108728118, 2021
762021
Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome
RA Quinn, S Adem, RH Mills, W Comstock, L DeRight Goldasich, ...
Microbiome 7, 1-13, 2019
652019
A charge‐switchable zwitterionic peptide for rapid detection of SARS‐CoV‐2 main protease
Z Jin, Y Mantri, M Retout, Y Cheng, J Zhou, A Jorns, P Fajtova, W Yim, ...
Angewandte Chemie 134 (9), e202112995, 2022
612022
Targeting proteasomes in infectious organisms to combat disease
B Bibo‐Verdugo, Z Jiang, CR Caffrey, AJ O'Donoghue
The FEBS journal 284 (10), 1503-1517, 2017
612017
Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis
JL Small, AJ O'Donoghue, EC Boritsch, OV Tsodikov, GM Knudsen, ...
Journal of Biological Chemistry 288 (18), 12489-12499, 2013
532013
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