Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth JB Baell, DJ Leaver, SJ Hermans, GL Kelly, MS Brennan, NL Downer, ... Nature 560 (7717), 253-257, 2018 | 236 | 2018 |
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen, P Hickey, VC Wimmer, ... Nature immunology 21 (2), 168-177, 2020 | 173 | 2020 |
The TNF receptor superfamily-NF-κB axis is critical to maintain effector regulatory T cells in lymphoid and non-lymphoid tissues A Vasanthakumar, Y Liao, P Teh, MF Pascutti, AE Oja, AL Garnham, ... Cell reports 20 (12), 2906-2920, 2017 | 139 | 2017 |
SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition TA Nguyen, BRC Smith, MD Tate, GT Belz, MH Barrios, KD Elgass, ... Immunity 47 (3), 498-509. e6, 2017 | 136 | 2017 |
Flexible usage and interconnectivity of diverse cell death pathways protect against intracellular infection M Doerflinger, Y Deng, P Whitney, R Salvamoser, S Engel, AJ Kueh, L Tai, ... Immunity 53 (3), 533-547. e7, 2020 | 122 | 2020 |
An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell MJ Coffey, BE Sleebs, AD Uboldi, A Garnham, M Franco, ND Marino, ... Elife 4, e10809, 2015 | 119 | 2015 |
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis T Sidwell, Y Liao, AL Garnham, A Vasanthakumar, R Gloury, J Blume, ... Nature Communications 11 (1), 252, 2020 | 78 | 2020 |
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer SA Best, PM Gubser, S Sethumadhavan, A Kersbergen, YLN Abril, ... Cell Metabolism 34 (6), 874-887. e6, 2022 | 77 | 2022 |
Extracellular vesicles from early stage Plasmodium falciparum‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes NG Sampaio, SJ Emery, AL Garnham, QY Tan, X Sisquella, MA Pimentel, ... Cellular Microbiology 20 (5), e12822, 2018 | 73 | 2018 |
Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy R Thijssen, L Tian, MA Anderson, C Flensburg, A Jarratt, AL Garnham, ... Blood, The Journal of the American Society of Hematology 140 (20), 2127-2141, 2022 | 61 | 2022 |
Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate SY Ma'Ayeh, L Knörr, K Sköld, A Garnham, BRE Ansell, AR Jex, SG Svärd Frontiers in cellular and infection microbiology 8, 244, 2018 | 47 | 2018 |
Multi-level remodelling of chromatin underlying activation of human T cells NG Bediaga, HD Coughlan, TM Johanson, AL Garnham, G Naselli, ... Scientific reports 11 (1), 528, 2021 | 46 | 2021 |
Dysregulated IL-1β-GM-CSF axis in acute rheumatic fever that is limited by hydroxychloroquine ML Kim, WJ Martin, G Minigo, JL Keeble, AL Garnham, G Pacini, ... Circulation 138 (23), 2648-2661, 2018 | 42 | 2018 |
Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice S Alvarez-Diaz, A Preaudet, AL Samson, PM Nguyen, KY Fung, ... Cell Death & Differentiation 28 (5), 1466-1476, 2021 | 41 | 2021 |
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia HM McRae, AL Garnham, Y Hu, MT Witkowski, MA Corbett, MP Dixon, ... Blood, The Journal of the American Society of Hematology 133 (16), 1729-1741, 2019 | 41 | 2019 |
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a BJ Shields, JT Jackson, D Metcalf, W Shi, Q Huang, AL Garnham, ... Genes & development 30 (1), 78-91, 2016 | 40 | 2016 |
The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal Y Yang, AJ Kueh, ZL Grant, W Abeysekera, AL Garnham, S Wilcox, ... Blood, The Journal of the American Society of Hematology 139 (6), 845-858, 2022 | 39 | 2022 |
Design, synthesis, and biological activity of 1, 2, 3-triazolobenzodiazepine BET bromodomain inhibitors PP Sharp, JM Garnier, T Hatfaludi, Z Xu, D Segal, KE Jarman, H Jousset, ... ACS Medicinal Chemistry Letters 8 (12), 1298-1303, 2017 | 33 | 2017 |
Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice S Tyebji, S Seizova, AL Garnham, AJ Hannan, CJ Tonkin Brain, behavior, and immunity 80, 88-108, 2019 | 32 | 2019 |
Extracellular vesicles in synovial fluid from rheumatoid arthritis patients contain miRNAs with capacity to modulate inflammation AD Foers, AL Garnham, S Chatfield, GK Smyth, L Cheng, AF Hill, IP Wicks, ... International Journal of Molecular Sciences 22 (9), 4910, 2021 | 29 | 2021 |