Daniel Martinez Molina
Daniel Martinez Molina
CSO at Pelago Bioscience, Sweden
Verified email at - Homepage
Cited by
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Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
DM Molina, R Jafari, M Ignatushchenko, T Seki, EA Larsson, C Dan, ...
Science 341 (6141), 84-87, 2013
The cellular thermal shift assay for evaluating drug target interactions in cells
R Jafari, H Almqvist, H Axelsson, M Ignatushchenko, T Lundbäck, ...
Nature protocols 9 (9), 2100-2122, 2014
Tracking cancer drugs in living cells by thermal profiling of the proteome
MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ...
Science 346 (6205), 1255784, 2014
The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies
D Martinez Molina, P Nordlund
Annual review of pharmacology and toxicology 56 (1), 141-161, 2016
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution
S Eshaghi, D Niegowski, A Kohl, DM Molina, SA Lesley, P Nordlund
Science 313 (5785), 354-357, 2006
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase
DM Molina, A Wetterholm, A Kohl, AA McCarthy, D Niegowski, E Ohlson, ...
Nature 448 (7153), 613-616, 2007
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ...
Nature communications 7 (1), 11040, 2016
Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6
W McCoull, T Cheung, E Anderson, P Barton, J Burgess, K Byth, Q Cao, ...
ACS Chemical Biology 13 (11), 3131-3141, 2018
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site
JC Exell, MJ Thompson, LD Finger, SJ Shaw, J Debreczeni, TA Ward, ...
Nature chemical biology 12 (10), 815-821, 2016
Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay
J Shaw, M Leveridge, C Norling, J Karén, DM Molina, D O’Neill, ...
Scientific Reports 8 (1), 163, 2018
Catalysis within the lipid bilayer—structure and mechanism of the MAPEG family of integral membrane proteins
DM Molina, S Eshaghi, P Nordlund
Current opinion in structural biology 18 (4), 442-449, 2008
CETSA: a target engagement assay with potential to transform drug discovery
AJ Jensen, DM Molina, T Lundbäck
Future medicinal chemistry 7 (8), 975-978, 2015
Engineering membrane protein overproduction in Escherichia coli
DM Molina, T Cornvik, S Eshaghi, JZ Haeggström, P Nordlund, MI Sabet
Protein Science 17 (4), 673-680, 2008
Positioning high-throughput CETSA in early drug discovery through screening against B-Raf and PARP1
J Shaw, I Dale, P Hemsley, L Leach, N Dekki, JP Orme, V Talbot, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 24 (2), 121-132, 2019
Arginine 104 is a key catalytic residue in leukotriene C4 synthase
A Rinaldo-Matthis, A Wetterholm, DM Molina, J Holm, D Niegowski, ...
Journal of Biological Chemistry 285 (52), 40771-40776, 2010
The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme
CS Andersson, CAK Lundgren, A Magnúsdóttir, C Ge, Å Wieslander, ...
Structure 20 (6), 1062-1070, 2012
A tale of two tails: efficient profiling of protein degraders by specific functional and target engagement readouts
AL Chernobrovkin, C Cázares-Körner, T Friman, IM Caballero, D Amadio, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (4), 534-546, 2021
CETSA MS profiling for a comparative assessment of FDA-approved antivirals repurposed for COVID-19 therapy identifies TRIP13 as a remdesivir off-target
T Friman, A Chernobrovkin, D Martinez Molina, L Arnold
SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (3), 336-344, 2021
Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between brassinosteroid and auxin signaling
Q Lu, Y Zhang, J Hellner, C Giannini, X Xu, J Pauwels, Q Ma, W Dejonghe, ...
Proceedings of the National Academy of Sciences 119 (11), e2118220119, 2022
Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A (hTrkA) Inhibitors
G Subramanian, PD Johnson, T Zachary, N Roush, Y Zhu, SJ Bowen, ...
ACS Chemical Biology 14 (6), 1205-1216, 2019
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