| Highly enantioselective and substrate-selective polymers obtained by molecular imprinting utilizing noncovalent interactions. NMR and chromatographic studies on the nature of … B Sellergren, M Lepistoe, K Mosbach Journal of the American chemical society 110 (17), 5853-5860, 1988 | 769 | 1988 |
| Ligand binding mechanism in steroid receptors: from conserved plasticity to differential evolutionary constraints K Edman, A Hosseini, MK Bjursell, A Aagaard, L Wissler, A Gunnarsson, ... Structure 23 (12), 2280-2290, 2015 | 108 | 2015 |
| Novel conserved hydrolase domain in the CLCA family of alleged calcium‐activated chloride channels K Pawłowski, M Lepistö, N Meinander, U Sivars, M Varga, E Wieslander Proteins: Structure, Function, and Bioinformatics 63 (3), 424-439, 2006 | 81 | 2006 |
| Discovery of a novel oral glucocorticoid receptor modulator (AZD9567) with improved side effect profile L Ripa, K Edman, M Dearman, G Edenro, R Hendrickx, V Ullah, ... Journal of Medicinal Chemistry 61 (5), 1785-1799, 2018 | 70 | 2018 |
| Discrimination between amino acid amide conformers by imprinted polymers M Lepistoe, B Sellergren The Journal of Organic Chemistry 54 (26), 6010-6012, 1989 | 69 | 1989 |
| Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic acid bioisostere N Pemberton, H Graden, E Evertsson, E Bratt, M Lepistö, ... ACS Medicinal Chemistry Letters 3 (7), 574-578, 2012 | 58 | 2012 |
| Selective nonsteroidal glucocorticoid receptor modulators for the inhaled treatment of pulmonary diseases M Hemmerling, S Nilsson, K Edman, S Eirefelt, W Russell, R Hendrickx, ... Journal of Medicinal Chemistry 60 (20), 8591-8605, 2017 | 55 | 2017 |
| Chemical Compounds 572 M Berger, J Dahmén, K Edman, A Eriksson, B Gabos, T Hansson, ... US Patent App. 13/429,177, 2012 | 51 | 2012 |
| HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase J Evenäs, F Edfeldt, M Lepistö, N Svitacheva, A Synnergren, B Lundquist, ... Bioorganic & Medicinal Chemistry Letters 24 (5), 1315-1321, 2014 | 39 | 2014 |
| 2-Pyridone derivatives as inhibitors of neutrophile elastase H Bladh, T Klingstedt, J Larsson, K Lawitz, M Lepisto, H Lonn, G Nikitidis US Patent App. 10/534,720, 2006 | 36 | 2006 |
| The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation K Edman, R Ahlgren, M Bengtsson, H Bladh, S Bäckström, J Dahmén, ... Bioorganic & medicinal chemistry letters 24 (11), 2571-2577, 2014 | 35 | 2014 |
| Potent and orally bioavailable inverse agonists of RORγt resulting from structure-based design F Narjes, Y Xue, S von Berg, J Malmberg, A Llinas, RI Olsson, J Jirholt, ... Journal of Medicinal Chemistry 61 (17), 7796-7813, 2018 | 34 | 2018 |
| Metalloproteinase inhibitors A Eriksson, M Lepistö, M Lundkvist, MMA Rosenschöld, P Zlatoidsky US Patent 7,427,631, 2008 | 34 | 2008 |
| Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor C Köhler, G Carlström, A Gunnarsson, U Weininger, S Tångefjord, V Ullah, ... Science Advances 6 (29), eabb5277, 2020 | 33 | 2020 |
| Determination of the degree of derivatization of acryloylated polysaccharides by Fourier transform proton NMR spectroscopy M Lepistö, P Artursson, P Edman, T Laakso, I Sjöholm Analytical biochemistry 133 (1), 132-135, 1983 | 31 | 1983 |
| Saccharin Aza Bioisosteres Synthesis and Preclinical Property Comparisons Y Chen, CJ Aurell, A Pettersen, RJ Lewis, MA Hayes, M Lepistö, ... ACS Medicinal Chemistry Letters 8 (6), 672-677, 2017 | 30 | 2017 |
| Protein kinase inhibitors K Karabelas, M Lepistö, P Sjö US Patent 6,346,625, 2002 | 29* | 2002 |
| The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits I Mitxitorena, D Somma, JP Mitchell, M Lepistö, C Tyrchan, EL Smith, ... Journal of Biological Chemistry 295 (33), 11754-11763, 2020 | 26 | 2020 |
| Metalloproteinase inhibitors M Lepisto, MMA Rosenschold US Patent App. 10/471,499, 2004 | 25 | 2004 |
| Arrangement of pressure nozzles for the treatment of webs M Lepisto US Patent 4,932,140, 1990 | 25 | 1990 |
Anders R ErikssonMedicinal Chemistry, RIA iMed, AstraZenecaVerified email at astrazeneca.com
