| Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid J Pugin, R Auckenthaler, N Mili, JP Janssens, PD Lew, PM Suter American Review of Respiratory Disease 143 (5_pt_1), 1121-1129, 1991 | 1555 | 1991 |
| Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis S Harbarth, K Holeckova, C Froidevaux, D Pittet, B Ricou, GE Grau, ... American journal of respiratory and critical care medicine 164 (3), 396-402, 2001 | 1411 | 2001 |
| Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. J Pugin, CC Schürer-Maly, D Leturcq, A Moriarty, RJ Ulevitch, PS Tobias Proceedings of the National Academy of Sciences 90 (7), 2744-2748, 1993 | 1077 | 1993 |
| Protection from septic shock by neutralization of macrophage migration inhibitory factor T Calandra, B Echtenacher, DL Roy, J Pugin, CN Metz, L Hültner, ... Nature medicine 6 (2), 164-170, 2000 | 1031 | 2000 |
| CD14 is a pattern recognition receptor J Pugin, D Heumann, A Tomasz, VV Kravchenko, Y Akamatsu, ... Immunity 1 (6), 509-516, 1994 | 902 | 1994 |
| Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial V Nobre, S Harbarth, JD Graf, P Rohner, J Pugin American journal of respiratory and critical care medicine 177 (5), 498-505, 2008 | 896 | 2008 |
| Cytokine-mediated inflammation in acute lung injury RB Goodman, J Pugin, JS Lee, MA Matthay Cytokine & growth factor reviews 14 (6), 523-535, 2003 | 878 | 2003 |
| Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis S Harbarth, J Garbino, J Pugin, JA Romand, D Lew, D Pittet The American journal of medicine 115 (7), 529-535, 2003 | 842 | 2003 |
| Cytokine balance in the lungs of patients with acute respiratory distress syndrome WY Park, RB Goodman, KP Steinberg, JT Ruzinski, F RADELLA, DR Park, ... American journal of respiratory and critical care medicine 164 (10), 1896-1903, 2001 | 786 | 2001 |
| Normal responses to injury prevent systemic inflammation and can be immunosuppressive RS Munford, J Pugin American journal of respiratory and critical care medicine 163 (2), 316-321, 2001 | 737 | 2001 |
| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 722 | 2021 |
| The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome J Pugin, G Verghese, MC Widmer, MA Matthay Critical care medicine 27 (2), 304-312, 1999 | 622 | 1999 |
| Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure P Saudan, M Niederberger, S De Seigneux, J Romand, J Pugin, ... Kidney international 70 (7), 1312-1317, 2006 | 552 | 2006 |
| Activation of human macrophages by mechanical ventilation in vitro J Pugin, I Dunn, P Jolliet, D Tassaux, JL Magnenat, LP Nicod, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 275 (6 …, 1998 | 506 | 1998 |
| Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. J Pugin, B Ricou, KP Steinberg, PM Suter, TR Martin American journal of respiratory and critical care medicine 153 (6), 1850-1856, 1996 | 426 | 1996 |
| Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia: a randomized, placebo-controlled, double-blind clinical trial J Pugin, R Auckenthaler, DP Lew, PM Suter Jama 265 (20), 2704-2710, 1991 | 396 | 1991 |
| Endocan, a new endothelial marker in human sepsis A Scherpereel, F Depontieu, B Grigoriu, B Cavestri, A Tsicopoulos, ... Critical care medicine 34 (2), 532-537, 2006 | 352 | 2006 |
| Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus I Tillie-Leblond, J Pugin, CH Marquette, C Lamblin, F Saulnier, A Brichet, ... American journal of respiratory and critical care medicine 159 (2), 487-494, 1999 | 341 | 1999 |
| Mitochondrial damage-associated molecular patterns: from inflammatory signaling to human diseases S Grazioli, J Pugin Frontiers in immunology 9, 342896, 2018 | 329 | 2018 |
| Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome G Drifte, I Dunn-Siegrist, P Tissières, J Pugin Critical care medicine 41 (3), 820-832, 2013 | 303 | 2013 |
