Kin Chung Lam
Kin Chung Lam
MGH/ Harvard Medical School
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High-resolution TADs reveal DNA sequences underlying genome organization in flies
F Ramírez, V Bhardwaj, L Arrigoni, KC Lam, BA Grüning, J Villaveces, ...
Nature communications 9 (1), 189, 2018
PrimeDesign software for rapid and simplified design of prime editing guide RNAs
JY Hsu, J Grünewald, R Szalay, J Shih, AV Anzalone, KC Lam, MW Shen, ...
Nature Communications 12 (1), 1034, 2021
The NSL Complex Regulates Housekeeping Genes in Drosophila
KC Lam, F Muehlpfordt, JM Vaquerizas, SJ Raja, H Holz, NM Luscombe, ...
PLoS genetics 8 (6), e1002736, 2012
High-affinity sites form an interaction network to facilitate spreading of the MSL complex across the X chromosome in Drosophila
F Ramirez, T Lingg, S Toscano, KC Lam, P Georgiev, HR Chung, ...
Molecular cell 60 (1), 146-162, 2015
The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise
KC Lam, HR Chung, G Semplicio, SS Iyer, A Gaub, V Bhardwaj, H Holz, ...
Genes & Development 33 (7-8), 452-465, 2019
MOSAIC enables in situ saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells
JY Hsu, KC Lam, J Shih, L Pinello, JK Joung
bioRxiv, 2024.04. 25.591078, 2024
CRISPR PERSIST-On enables heritable and fine-tunable human gene activation
YE Tak, JY Hsu, J Shih, HT Schultz, IT Nguyen, KC Lam, L Pinello, ...
bioRxiv, 2024.04. 26.590475, 2024
MOSAIC Enables In Situ Saturation Mutagenesis of Genes and Optimization of CRISPR Prime Editor Activities in Human Cells
JY Hsu, KC Lam, JY Shih, L Pinello, K Joung
MOLECULAR THERAPY 30 (5), 2-2, 2022
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