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Pavlina Rezacova
Pavlina Rezacova
Head of Structural Biology, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
Verified email at uochb.cas.cz
Title
Cited by
Cited by
Year
From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease
P Cígler, M Kožíšek, P Řezáčová, J Brynda, Z Otwinowski, J Pokorná, ...
Proceedings of the National Academy of Sciences 102 (43), 15394-15399, 2005
3482005
Link between a novel human γD-crystallin allele and a unique cataract phenotype explained by protein crystallography
S Kmoch, J Brynda, B Asfaw, K Bezouška, P Novák, P Řezáčová, ...
Human molecular genetics 9 (12), 1779-1786, 2000
2032000
A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation
J Chmelar, CJ Oliveira, P Rezacova, IMB Francischetti, Z Kovarova, ...
Blood, The Journal of the American Society of Hematology 117 (2), 736-744, 2011
1702011
Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel
T Koudelakova, R Chaloupkova, J Brezovsky, Z Prokop, E Sebestova, ...
Angewandte Chemie 125 (7), 2013-2017, 2013
1632013
Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes
P Rezacova, J Pokorná, J Brynda, M Kozisek, P Cígler, M Lepsik, ...
Journal of medicinal chemistry 52 (22), 7132-7141, 2009
1602009
Current and novel inhibitors of HIV protease
J Pokorná, L Machala, P Řezáčová, J Konvalinka
Viruses 1 (3), 1209-1239, 2009
1332009
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance
M Kožíšek, P Cígler, M Lepšík, J Fanfrlík, P Řezáčová, J Brynda, ...
Journal of medicinal chemistry 51 (15), 4839-4843, 2008
1142008
Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants
M Kožíšek, J Bray, P Řezáčová, K Šašková, J Brynda, J Pokorná, ...
Journal of molecular biology 374 (4), 1005-1016, 2007
1082007
Engineering a de novo transport tunnel
J Brezovsky, P Babkova, O Degtjarik, A Fortova, A Gora, I Iermak, ...
ACS Catalysis 6 (11), 7597-7610, 2016
1052016
Carborane-based carbonic anhydrase inhibitors
J Brynda, P Mader, V Šícha, M Fábry, K Poncová, M Bakardiev, B Grüner, ...
Angew Chem Int Ed Engl 52 (51), 13760-3, 2013
1012013
Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni
A Jilkova, P Řezáčová, M Lepšík, M Horn, J Váchová, J Fanfrlík, J Brynda, ...
Journal of Biological Chemistry 286 (41), 35770-35781, 2011
902011
Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata
J Salát, GC Paesen, P Řezáčová, M Kotsyfakis, Z Kovářová, M Šanda, ...
Biochemical Journal 429 (1), 103-112, 2010
892010
Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold
J Schimer, P Cígler, J Vesely, K Grantz Šašková, M Lepsik, J Brynda, ...
Journal of Medicinal Chemistry 55 (22), 10130-10135, 2012
692012
Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir
KG Šašková, M Kožíšek, P Rˇezácová, J Brynda, T Yashina, ...
Journal of virology 83 (17), 8810-8818, 2009
682009
Thermodynamic and structural analysis of HIV protease resistance to darunavir–analysis of heavily mutated patient‐derived HIV‐1 proteases
M Kožíšek, M Lepšík, K Grantz Šašková, J Brynda, J Konvalinka, ...
The FEBS journal 281 (7), 1834-1847, 2014
642014
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
P Tesina, K Čermáková, M Hořejší, K Procházková, M Fábry, S Sharma, ...
Nature communications 6 (1), 7968, 2015
612015
Metallacarborane sulfamides: Unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX
B Grüner, J Brynda, V Das, V Šícha, J Štěpánková, J Nekvinda, ...
Journal of Medicinal Chemistry 62 (21), 9560-9575, 2019
572019
Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region
M Kožíšek, KG Šašková, P Řezáčová, J Brynda, ...
Journal of virology 82 (12), 5869-5878, 2008
562008
Balancing the stability–activity trade‐off by fine‐tuning dehalogenase access tunnels
V Liskova, D Bednar, T Prudnikova, P Rezacova, T Koudelakova, ...
ChemCatChem 7 (4), 648-659, 2015
542015
Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease
M Kožíšek, S Henke, KG Šašková, GB Jacobs, A Schuch, B Buchholz, ...
Antimicrobial agents and chemotherapy 56 (8), 4320-4330, 2012
542012
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