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Fiona Pachl
Fiona Pachl
Verified email at astrazeneca.com
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Year
Measuring and managing ratio compression for accurate iTRAQ/TMT quantification
MM Savitski, T Mathieson, N Zinn, G Sweetman, C Doce, I Becher, ...
Journal of proteome research 12 (8), 3586-3598, 2013
2782013
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments
H Hahne, F Pachl, B Ruprecht, SK Maier, S Klaeger, D Helm, G Médard, ...
Nature methods 10 (10), 989-991, 2013
2502013
EED-targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex
JHR Hsu, T Rasmusson, J Robinson, F Pachl, J Read, S Kawatkar, ...
Cell chemical biology 27 (1), 41-46. e17, 2020
1652020
The timely deposition of callose is essential for cytokinesis in Arabidopsis
K Thiele, G Wanner, V Kindzierski, G Jürgens, U Mayer, F Pachl, ...
The Plant Journal 58 (1), 13-26, 2009
1462009
Optimized chemical proteomics assay for kinase inhibitor profiling
G Médard, F Pachl, B Ruprecht, S Klaeger, S Heinzlmeir, D Helm, H Qiao, ...
Journal of proteome research 14 (3), 1574-1586, 2015
1382015
Proteolysis‐targeting chimeras in drug development: a safety perspective
K Moreau, M Coen, AX Zhang, F Pachl, MP Castaldi, G Dahl, H Boyd, ...
British journal of pharmacology 177 (8), 1709-1718, 2020
1292020
Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
D Helm, JPC Vissers, CJ Hughes, H Hahne, B Ruprecht, F Pachl, A Grzyb, ...
Molecular & Cellular Proteomics 13 (12), 3709-3715, 2014
1212014
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper …
JW Johannes, A Balazs, D Barratt, M Bista, MD Chuba, S Cosulich, ...
Journal of Medicinal Chemistry 64 (19), 14498-14512, 2021
592021
Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1
M Raab, A Krämer, S Hehlgans, M Sanhaji, E Kurunci-Csacsko, C Dötsch, ...
Molecular oncology 9 (1), 140-154, 2015
562015
Co‐immunoprecipitation‐based identification of putative BAX INHIBITOR‐1‐interacting proteins involved in cell death regulation and plant–powdery mildew interactions
C Weis, S Pfeilmeier, E Glawischnig, E Isono, F Pachl, H Hahne, B Kuster, ...
Molecular plant pathology 14 (8), 791-802, 2013
492013
Novel Flp pilus biogenesis-dependent natural transformation
A Angelov, P Bergen, F Nadler, P Hornburg, A Lichev, M Übelacker, ...
Frontiers in Microbiology 6, 84, 2015
432015
Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase
SL Degorce, O Tavana, E Banks, C Crafter, L Gingipalli, D Kouvchinov, ...
Journal of Medicinal Chemistry 63 (18), 10460-10473, 2020
422020
Characterization of a chemical affinity probe targeting Akt kinases
F Pachl, P Plattner, B Ruprecht, G Medard, N Sewald, B Kuster
Journal of Proteome Research 12 (8), 3792-3800, 2013
402013
Software tools for MS-based quantitative proteomics: a brief overview
S Lemeer, H Hahne, F Pachl, B Kuster
Quantitative methods in proteomics, 489-499, 2012
402012
Reduced mitochondrial mass and function add to age‐related susceptibility toward diet‐induced fatty liver in C57BL/6J mice
K Lohr, F Pachl, A Moghaddas Gholami, KE Geillinger, H Daniel, B Kuster, ...
Physiological reports 4 (19), e12988, 2016
382016
Towards understanding male infertility after spinal cord injury using quantitative proteomics
BF da Silva, C Meng, D Helm, F Pachl, J Schiller, E Ibrahim, CM Lynne, ...
Molecular & Cellular Proteomics 15 (4), 1424-1434, 2016
322016
Abstract LB-273: A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and …
E Leo, J Johannes, G Illuzzi, A Zhang, P Hemsley, MJ Bista, JP Orme, ...
Cancer Research 78 (13_Supplement), LB-273-LB-273, 2018
262018
Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells
M Raab, F Pachl, A Krämer, E Kurunci-Csacsko, C Dötsch, R Knecht, ...
Cell research 24 (9), 1141-1145, 2014
212014
Characterization of a high field O rbitrap mass spectrometer for proteome analysis
F Pachl, B Ruprecht, S Lemeer, B Kuster
Proteomics 13 (17), 2552-2562, 2013
182013
Proteomic and metabolite profiling reveals profound structural and metabolic reorganization of adipocyte mitochondria in obesity
T Schöttl, F Pachl, P Giesbertz, H Daniel, B Kuster, T Fromme, ...
Obesity 28 (3), 590-600, 2020
162020
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