| An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus D Lamarre, PC Anderson, M Bailey, P Beaulieu, G Bolger, P Bonneau, ... Nature 426 (6963), 186-189, 2003 | 1141 | 2003 |
| The challenge of atropisomerism in drug discovery J Clayden, WJ Moran, PJ Edwards, SR LaPlante Angewandte Chemie International Edition 48 (35), 6398-6401, 2009 | 658 | 2009 |
| Assessing atropisomer axial chirality in drug discovery and development SR LaPlante, LD Fader, KR Fandrick, DR Fandrick, O Hucke, R Kemper, ... Journal of medicinal chemistry 54 (20), 7005-7022, 2011 | 595 | 2011 |
| Revealing atropisomer axial chirality in drug discovery SR LaPlante, PJ Edwards, LD Fader, A Jakalian, O Hucke ChemMedChem 6 (3), 505-513, 2011 | 404 | 2011 |
| Peptide-based inhibitors of the hepatitis C virus serine protease M Llinas-Brunet, M Bailey, G Fazal, S Goulet, T Halmos, S Laplante, ... Bioorganic & Medicinal Chemistry Letters 8 (13), 1713-1718, 1998 | 284 | 1998 |
| Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection YS Tsantrizos, G Bolger, P Bonneau, DR Cameron, N Goudreau, G Kukolj, ... Angewandte Chemie 115 (12), 1394-1398, 2003 | 260 | 2003 |
| Discovery of BI 224436, a noncatalytic site integrase inhibitor (NCINI) of HIV-1 LD Fader, E Malenfant, M Parisien, R Carson, F Bilodeau, S Landry, ... ACS medicinal chemistry letters 5 (4), 422-427, 2014 | 163 | 2014 |
| Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives PL Beaulieu, M Bös, Y Bousquet, G Fazal, J Gauthier, J Gillard, S Goulet, ... Bioorganic & medicinal chemistry letters 14 (1), 119-124, 2004 | 147 | 2004 |
| Atropisomerie als Herausforderung in der Medikamentenentwicklung J Clayden, WJ Moran, PJ Edwards, SR LaPlante Angewandte Chemie 121 (35), 6516-6520, 2009 | 131 | 2009 |
| Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists SR LaPlante, R Carson, J Gillard, N Aubry, R Coulombe, S Bordeleau, ... Journal of Medicinal Chemistry 56 (12), 5142-5150, 2013 | 123 | 2013 |
| Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor C Fenwick, M Amad, MD Bailey, R Bethell, M Bös, P Bonneau, ... Antimicrobial agents and chemotherapy 58 (6), 3233-3244, 2014 | 114 | 2014 |
| Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate G McKercher, PL Beaulieu, D Lamarre, S LaPlante, S Lefebvre, C Pellerin, ... Nucleic acids research 32 (2), 422-431, 2004 | 112 | 2004 |
| 13C-NMR relaxation in three DNA oligonucleotide duplexes: model-free analysis of internal and overall motion PN Borer, SR LaPlante, A Kumar, N Zanatta, A Martin, A Hakkinen, ... Biochemistry 33 (9), 2441-2450, 1994 | 112 | 1994 |
| Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds PL Beaulieu, J Gillard, D Bykowski, C Brochu, N Dansereau, JS Duceppe, ... Bioorganic & medicinal chemistry letters 16 (19), 4987-4993, 2006 | 109 | 2006 |
| Solution structure of substrate-based ligands when bound to hepatitis C virus NS3 protease domain SR LaPlante, DR Cameron, N Aubry, S Lefebvre, G Kukolj, R Maurice, ... Journal of Biological Chemistry 274 (26), 18618-18624, 1999 | 104 | 1999 |
| Synthesis and biological activity of hydrazones and derivatives: A review J de Oliveira Carneiro Brum, TCC França, SR LaPlante, JDF Villar Mini reviews in medicinal chemistry 20 (5), 342-368, 2020 | 76 | 2020 |
| Inhibitors of human immunodeficiency virus replication C Yoakim, M Bailey, F Bilodeau, R Carson, L Fader, S Kawai, S Morin, ... US Patent 8,338,441, 2012 | 68 | 2012 |
| NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain SR LaPlante, N Aubry, PR Bonneau, G Kukolj, D Lamarre, S Lefebvre, ... Bioorganic & Medicinal Chemistry Letters 10 (20), 2271-2274, 2000 | 65 | 2000 |
| Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C … PL Beaulieu, M Bös, MG Cordingley, C Chabot, G Fazal, M Garneau, ... Journal of Medicinal Chemistry 55 (17), 7650-7666, 2012 | 60 | 2012 |
| Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy SR LaPlante, A Jakalian, N Aubry, Y Bousquet, JM Ferland, J Gillard, ... Angewandte Chemie 116 (33), 4406-4411, 2004 | 60 | 2004 |
