| A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo L Bai, H Zhou, R Xu, Y Zhao, K Chinnaswamy, D McEachern, J Chen, ... Cancer cell 36 (5), 498-511. e17, 2019 | 430 | 2019 |
| Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression B Zhou, J Hu, F Xu, Z Chen, L Bai, E Fernandez-Salas, M Lin, L Liu, ... Journal of medicinal chemistry 61 (2), 462-481, 2018 | 361 | 2018 |
| Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo D Borkin, S He, H Miao, K Kempinska, J Pollock, J Chase, T Purohit, ... Cancer cell 27 (4), 589-602, 2015 | 354 | 2015 |
| Discovery of QCA570 as an exceptionally potent and efficacious proteolysis targeting chimera (PROTAC) degrader of the bromodomain and extra-terminal (BET) proteins capable of … C Qin, Y Hu, B Zhou, E Fernandez-Salas, CY Yang, L Liu, D McEachern, ... Journal of medicinal chemistry 61 (15), 6685-6704, 2018 | 245 | 2018 |
| Targeted degradation of BET proteins in triple-negative breast cancer L Bai, B Zhou, CY Yang, J Ji, D McEachern, S Przybranowski, H Jiang, ... Cancer research 77 (9), 2476-2487, 2017 | 196 | 2017 |
| Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5 … A Aguilar, J Lu, L Liu, D Du, D Bernard, D McEachern, S Przybranowski, ... Journal of medicinal chemistry 60 (7), 2819-2839, 2017 | 176 | 2017 |
| Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia S Klossowski, H Miao, K Kempinska, T Wu, T Purohit, EG Kim, ... The Journal of clinical investigation 130 (2), 981-997, 2020 | 165 | 2020 |
| Structure-based discovery of SD-36 as a potent, selective, and efficacious PROTAC degrader of STAT3 protein H Zhou, L Bai, R Xu, Y Zhao, J Chen, D McEachern, K Chinnaswamy, ... Journal of medicinal chemistry 62 (24), 11280-11300, 2019 | 154 | 2019 |
| Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome O Rom, Y Liu, Z Liu, Y Zhao, J Wu, A Ghrayeb, L Villacorta, Y Fan, ... Science translational medicine 12 (572), eaaz2841, 2020 | 140 | 2020 |
| Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs B Hens, Y Tsume, M Bermejo, P Paixao, MJ Koenigsknecht, JR Baker, ... Molecular pharmaceutics 14 (12), 4281-4294, 2017 | 118 | 2017 |
| Discovery of ARD-2585 as an exceptionally potent and orally active PROTAC degrader of androgen receptor for the treatment of advanced prostate cancer W Xiang, L Zhao, X Han, C Qin, B Miao, D McEachern, Y Wang, ... Journal of medicinal chemistry 64 (18), 13487-13509, 2021 | 94 | 2021 |
| Discovery of a highly potent, cell-permeable macrocyclic peptidomimetic (MM-589) targeting the WD repeat domain 5 protein (WDR5)–mixed lineage leukemia (MLL) protein–protein … H Karatas, Y Li, L Liu, J Ji, S Lee, Y Chen, J Yang, L Huang, D Bernard, ... Journal of medicinal chemistry 60 (12), 4818-4839, 2017 | 90 | 2017 |
| Strategies toward discovery of potent and orally bioavailable proteolysis targeting chimera degraders of androgen receptor for the treatment of prostate cancer X Han, L Zhao, W Xiang, C Qin, B Miao, D McEachern, Y Wang, ... Journal of medicinal chemistry 64 (17), 12831-12854, 2021 | 84 | 2021 |
| Property focused structure-based optimization of small molecule inhibitors of the protein–protein interaction between menin and mixed lineage leukemia (MLL) D Borkin, J Pollock, K Kempinska, T Purohit, X Li, B Wen, T Zhao, H Miao, ... Journal of medicinal chemistry 59 (3), 892-913, 2016 | 75 | 2016 |
| In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions MJ Koenigsknecht, JR Baker, B Wen, A Frances, H Zhang, A Yu, T Zhao, ... Molecular pharmaceutics 14 (12), 4295-4304, 2017 | 67 | 2017 |
| BET bromodomain blockade mitigates intimal hyperplasia in rat carotid arteries B Wang, M Zhang, T Takayama, X Shi, DA Roenneburg, KC Kent, ... EBioMedicine 2 (11), 1650-1661, 2015 | 64 | 2015 |
| Complexity of blocking bivalent protein–protein interactions: development of a highly potent inhibitor of the menin–mixed-lineage leukemia interaction D Borkin, S Klossowski, J Pollock, H Miao, BM Linhares, K Kempinska, ... Journal of medicinal chemistry 61 (11), 4832-4850, 2018 | 51 | 2018 |
| Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract A Yu, JR Baker, AF Fioritto, Y Wang, R Luo, S Li, B Wen, M Bly, Y Tsume, ... Molecular pharmaceutics 14 (2), 345-358, 2017 | 50 | 2017 |
| Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma KM Hutchings, EM Lisabeth, W Rajeswaran, MW Wilson, RJ Sorenson, ... Bioorganic & medicinal chemistry letters 27 (8), 1744-1749, 2017 | 48 | 2017 |
| Reappraisal of anticancer nanomedicine design criteria in three types of preclinical cancer models for better clinical translation X Luan, H Yuan, Y Song, H Hu, B Wen, M He, H Zhang, Y Li, F Li, P Shu, ... Biomaterials 275, 120910, 2021 | 43 | 2021 |
