| Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection V Summa, A Petrocchi, F Bonelli, B Crescenzi, M Donghi, M Ferrara, ... Journal of medicinal chemistry 51 (18), 5843-5855, 2008 | 744 | 2008 |
| 4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good … V Summa, A Petrocchi, VG Matassa, C Gardelli, E Muraglia, M Rowley, ... Journal of medicinal chemistry 49 (23), 6646-6649, 2006 | 147 | 2006 |
| Enantioselective total synthesis of the antitumor macrolide rhizoxin D JA Lafontaine, DP Provencal, C Gardelli, JW Leahy The Journal of Organic Chemistry 68 (11), 4215-4234, 2003 | 127 | 2003 |
| Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors P Pace, ME Di Francesco, C Gardelli, S Harper, E Muraglia, E Nizi, ... Journal of Medicinal Chemistry 50 (9), 2225-2239, 2007 | 124 | 2007 |
| Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection F Narjes, C Gardelli, M Donghi, B Attenni, PL Durette US Patent 8,071,568, 2011 | 120 | 2011 |
| Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection M MacCoss, DB Olsen, M Donghi, C Gardelli, S Harper, M Meppen, ... US Patent 7,879,815, 2011 | 112 | 2011 |
| Regiochemical control of the ring opening of 1, 2-epoxides by means of chelating processes. 5. Synthesis and reactions of some 2, 3-epoxy-1-alkanol derivatives M Chini, P Crotti, LA Flippin, C Gardelli, E Giovani, F Macchia, M Pineschi The Journal of Organic Chemistry 58 (5), 1221-1227, 1993 | 106 | 1993 |
| Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection M Meppen, F Narjes, B Pacini, C Gardelli, PL Durette US Patent 8,148,349, 2012 | 94 | 2012 |
| Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones C Gardelli, E Nizi, E Muraglia, B Crescenzi, M Ferrara, F Orvieto, P Pace, ... Journal of medicinal chemistry 50 (20), 4953-4975, 2007 | 92 | 2007 |
| Regio-and stereoselective synthesis of β-halohydrins from 1, 2-epoxides with ammonium halides in the presence of metal salts M Chini, P Crotti, C Gardelli, F Macchia Tetrahedron 48 (18), 3805-3812, 1992 | 85 | 1992 |
| Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors E Muraglia, O Kinzel, C Gardelli, B Crescenzi, M Donghi, M Ferrara, E Nizi, ... Journal of medicinal chemistry 51 (4), 861-874, 2008 | 77 | 2008 |
| Phosphoramidate Prodrugs of 2′-C-Methylcytidine for Therapy of Hepatitis C Virus Infection C Gardelli, B Attenni, M Donghi, M Meppen, B Pacini, S Harper, ... Journal of medicinal chemistry 52 (17), 5394-5407, 2009 | 74 | 2009 |
| N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase B Crescenzi, C Gardelli, E Muraglia, F Orvieto, P Pace, G Pescatore, ... US Patent 7,169,780, 2007 | 68 | 2007 |
| Dihydroxypyrimidine carboxamide inhibitors of HIV integrase ME Di Francesco, C Gardelli, S Harper, VG Matassa, E Murgalia, E Nizi, ... US Patent 7,459,452, 2008 | 54 | 2008 |
| Dihydroxypyrimidine carboxamide inhibitors of HIV integrase ME Di Francesco, C Gardelli, S Harper, VG Matassa, E Murgalia, E Nizi, ... US Patent 7,232,819, 2007 | 54 | 2007 |
| Regiochemical control of the ring opening of 1, 2-epoxides by means of chelating processes. 8. Synthesis and ring opening reactions of cis-and trans-oxides derived from 3 … F Calvani, P Crotti, C Gardelli, M Pineschi Tetrahedron 50 (45), 12999-13022, 1994 | 54 | 1994 |
| Metal salt-promoted alcoholysis of 1, 2-epoxides M Chini, P Crotti, C Gardelli, F Macchia Synlett, 673-676, 1992 | 53 | 1992 |
| Regiochemical control of the ring opening of 1: 2-epoxides by means of chelating processes. 10. Synthesis and ring opening reactions of mono-and difunctionalized cis and trans … F Azzena, F Calvani, P Crotti, C Gardelli, F Macchia, M Pineschi Tetrahedron 51 (38), 10601-10626, 1995 | 48 | 1995 |
| The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease JM Ontoria, S Di Marco, I Conte, ME Di Francesco, C Gardelli, U Koch, ... Journal of medicinal chemistry 47 (26), 6443-6446, 2004 | 47 | 2004 |
| Antiviral Agents B Attenni, M Donghi, C Gardelli, M Meppen, F Narjes, B Pacini US Patent App. 12/601,002, 2010 | 46 | 2010 |
Nils PembertonMedicinal Chemistry, RIA iMed, AstraZenecaVerified email at astrazeneca.com
