Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement AV Cideciyan, SG Jacobson, WA Beltran, A Sumaroka, M Swider, S Iwabe, ... Proceedings of the National Academy of Sciences 110 (6), E517-E525, 2013 | 528 | 2013 |
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa WA Beltran, AV Cideciyan, AS Lewin, S Iwabe, H Khanna, A Sumaroka, ... Proceedings of the National Academy of Sciences 109 (6), 2132-2137, 2012 | 321 | 2012 |
Human cone photoreceptor dependence on RPE65 isomerase SG Jacobson, TS Aleman, AV Cideciyan, E Heon, M Golczak, WA Beltran, ... Proceedings of the National Academy of Sciences 104 (38), 15123-15128, 2007 | 172 | 2007 |
Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations WA Beltran, AV Cideciyan, KE Guziewicz, S Iwabe, M Swider, EM Scott, ... PloS one 9 (3), e90390, 2014 | 140 | 2014 |
A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa WA Beltran, P Hammond, GM Acland, GD Aguirre Investigative ophthalmology & visual science 47 (4), 1669-1681, 2006 | 135 | 2006 |
Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells BM Gaub, MH Berry, AE Holt, A Reiner, MA Kienzler, N Dolgova, ... Proceedings of the National Academy of Sciences 111 (51), E5574-E5583, 2014 | 130 | 2014 |
Bestrophinopathy is an RPE-photoreceptor interface disease KE Guziewicz, WA Beltran, S Iwabe, AV Cideciyan, SG Jacobson, ... Investigative Ophthalmology & Visual Science 57 (12), 2016 | 104 | 2016 |
rAAV2/5 gene-targeting to rods: dose-dependent efficiency and complications associated with different promoters WA Beltran, SL Boye, SE Boye, VA Chiodo, AS Lewin, WW Hauswirth, ... Gene therapy 17 (9), 1162-1174, 2010 | 93 | 2010 |
Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia AM Komáromy, JS Rowlan, ATP Corr, SL Reinstein, SL Boye, AE Cooper, ... Molecular Therapy 21 (6), 1131-1141, 2013 | 91 | 2013 |
BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure KE Guziewicz, AV Cideciyan, WA Beltran, AM Komáromy, VL Dufour, ... Proceedings of the National Academy of Sciences 115 (12), E2839-E2848, 2018 | 83 | 2018 |
Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease WA Beltran, AV Cideciyan, S Iwabe, M Swider, MS Kosyk, K McDaid, ... Proceedings of the National Academy of Sciences 112 (43), E5844-E5853, 2015 | 83 | 2015 |
Optimization of retinal gene therapy for X-linked retinitis pigmentosa due to RPGR mutations WA Beltran, AV Cideciyan, SE Boye, GJ Ye, S Iwabe, VL Dufour, ... Molecular Therapy 25 (8), 1866-1880, 2017 | 82 | 2017 |
Immunolocalization of ciliary neurotrophic factor receptor α (CNTFRα) in mammalian photoreceptor cells W Beltran, H Rohrer, GD Aguirre Molecular vision 11, 232, 2005 | 72 | 2005 |
Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects KE Guziewicz, B Zangerl, AM Komáromy, S Iwabe, VA Chiodo, SL Boye, ... PLoS One 8 (10), e75666, 2013 | 66 | 2013 |
Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor α (CNTFRα) WA Beltran, Q Zhang, JW Kijas, D Gu, H Rohrer, JA Jordan, GD Aguirre Investigative ophthalmology & visual science 44 (8), 3642-3649, 2003 | 63 | 2003 |
The use of canine models of inherited retinal degeneration to test novel therapeutic approaches WA Beltran Veterinary ophthalmology 12 (3), 192-204, 2009 | 58 | 2009 |
Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina WA Beltran, R Wen, GM Acland, GD Aguirre Experimental eye research 84 (4), 753-771, 2007 | 50 | 2007 |
Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus) WA Beltran, M Vanore, F Ollivet, F Nemoz‐Bertholet, F Aujard, B Clerc, ... Veterinary ophthalmology 10 (1), 43-49, 2007 | 44 | 2007 |
Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration S Genini, KE Guziewicz, WA Beltran, GD Aguirre BMC genomics 15 (1), 1, 2014 | 40 | 2014 |
Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina ÁI Berta, K Boesze-Battaglia, S Genini, O Goldstein, PJ O'Brien, Á Szél, ... PLoS One 6 (9), e24074, 2011 | 38 | 2011 |