Mamuka Kvaratskhelia
Mamuka Kvaratskhelia
University of Colorado School of Medicine
Verified email at - Homepage
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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
KA Jurado, H Wang, A Slaughter, L Feng, JJ Kessl, Y Koh, W Wang, ...
Proceedings of the National Academy of Sciences 110 (21), 8690-8695, 2013
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes
JO Eidahl, BL Crowe, JA North, CJ McKee, N Shkriabai, L Feng, M Plumb, ...
Nucleic acids research 41 (6), 3924-3936, 2013
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors
JJ Kessl, N Jena, Y Koh, H Taskent-Sezgin, A Slaughter, L Feng, ...
Journal of Biological Chemistry 287 (20), 16801-16811, 2012
BET proteins promote efficient murine leukemia virus integration at transcription start sites
A Sharma, RC Larue, MR Plumb, N Malani, F Male, A Slaughter, JJ Kessl, ...
Proceedings of the National Academy of Sciences 110 (29), 12036-12041, 2013
Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
DO Passos, M Li, R Yang, SV Rebensburg, R Ghirlando, Y Jeon, ...
Science 355 (6320), 89-92, 2017
Purification and characterization of a novel class III peroxidase isoenzyme from tea leaves
M Kvaratskhelia, C Winkel, RNF Thorneley
Plant Physiology 114 (4), 1237-1245, 1997
Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites
C Marchand, K Krajewski, HF Lee, S Antony, AA Johnson, R Amin, ...
Nucleic acids research 34 (18), 5157-5165, 2006
Interactions of HIV-1 Gag with assembly cofactors
N Shkriabai, SAK Datta, Z Zhao, S Hess, A Rein, M Kvaratskhelia
Biochemistry 45 (13), 4077-4083, 2006
Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein
CJ McKee, JJ Kessl, N Shkriabai, MJ Dar, A Engelman, M Kvaratskhelia
Journal of Biological Chemistry 283 (46), 31802-31812, 2008
Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch
SAK Datta, Z Zhao, PK Clark, S Tarasov, JN Alexandratos, SJ Campbell, ...
Journal of molecular biology 365 (3), 799-811, 2007
Molecular mechanisms of retroviral integration site selection
M Kvaratskhelia, A Sharma, RC Larue, E Serrao, A Engelman
Nucleic acids research 42 (16), 10209-10225, 2014
HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis
JJ Kessl, SB Kutluay, D Townsend, S Rebensburg, A Slaughter, RC Larue, ...
Cell 166 (5), 1257-1268. e12, 2016
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
SM Bester, G Wei, H Zhao, D Adu-Ampratwum, N Iqbal, VV Courouble, ...
Science 370 (6514), 360-364, 2020
A new class of multimerization selective inhibitors of HIV-1 integrase
A Sharma, A Slaughter, N Jena, L Feng, JJ Kessl, HJ Fadel, N Malani, ...
PLoS pathogens 10 (5), e1004171, 2014
The two analogous phosphoglycerate mutases of Escherichia coli
HI Fraser, M Kvaratskhelia, MF White
FEBS letters 455 (3), 344-348, 1999
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
M Kane, SV Rebensburg, MA Takata, TM Zang, M Yamashita, ...
Elife 7, e35738, 2018
LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
PK Singh, MR Plumb, AL Ferris, JR Iben, X Wu, HJ Fadel, BT Luke, ...
Genes & development 29 (21), 2287-2297, 2015
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding …
H Wang, KA Jurado, X Wu, MC Shun, X Li, AL Ferris, SJ Smith, PA Patel, ...
Nucleic acids research 40 (22), 11518-11530, 2012
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors
L Feng, A Sharma, A Slaughter, N Jena, Y Koh, N Shkriabai, RC Larue, ...
Journal of Biological Chemistry 288 (22), 15813-15820, 2013
Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A
SM Shell, Z Li, N Shkriabai, M Kvaratskhelia, C Brosey, MA Serrano, ...
Journal of Biological Chemistry 284 (36), 24213-24222, 2009
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