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Cheryl Wellington
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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
RK Graham, Y Deng, EJ Slow, B Haigh, N Bissada, G Lu, J Pearson, ...
Cell 125 (6), 1179-1191, 2006
8032006
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
MM Zeron, O Hansson, N Chen, CL Wellington, BR Leavitt, P Brundin, ...
Neuron 33 (6), 849-860, 2002
7392002
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
CL Wellington, LM Ellerby, AS Hackam, RL Margolis, MA Trifiro, ...
Journal of Biological Chemistry 273 (15), 9158-9167, 1998
7261998
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
HM Snyder, RA Corriveau, S Craft, JE Faber, SM Greenberg, D Knopman, ...
Alzheimer's & Dementia 11 (6), 710-717, 2015
6242015
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1
TS Tang, H Tu, EYW Chan, A Maximov, Z Wang, CL Wellington, ...
Neuron 39 (2), 227-239, 2003
6062003
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates
D Martindale, A Hackam, A Wieczorek, L Ellerby, C Wellington, ...
Nature genetics 18 (2), 150-154, 1998
5811998
Vascular dysfunction—the disregarded partner of Alzheimer's disease
MD Sweeney, A Montagne, AP Sagare, DA Nation, LS Schneider, ...
Alzheimer's & Dementia 15 (1), 158-167, 2019
5672019
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease
CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ...
Journal of Neuroscience 22 (18), 7862-7872, 2002
4992002
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
CL Wellington, L Ellerby, J Savill, S Roy, B Leavitt, E Cattaneo, A Hackam, ...
Journal of Biological Chemistry 275 (26), 19831-19838, 2000
4732000
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
MA Kalchman, HB Koide, K McCutcheon, RK Graham, K Nichol, ...
Nature genetics 16 (1), 44-53, 1997
4731997
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
SE Wahrle, H Jiang, M Parsadanian, J Kim, A Li, A Knoten, S Jain, ...
The Journal of clinical investigation 118 (2), 671-682, 2008
4432008
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
V Hirsch-Reinshagen, S Zhou, BL Burgess, L Bernier, SA McIsaac, ...
Journal of Biological Chemistry 279 (39), 41197-41207, 2004
4422004
The influence of huntingtin protein size on nuclear localization and cellular toxicity
AS Hackam, R Singaraja, CL Wellington, M Metzler, K McCutcheon, ...
The Journal of cell biology 141 (5), 1097-1105, 1998
4271998
Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus
J Gafni, E Hermel, JE Young, CL Wellington, MR Hayden, LM Ellerby
Journal of Biological Chemistry 279 (19), 20211-20220, 2004
4022004
ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation
CL Wellington, EKY Walker, A Suarez, A Kwok, N Bissada, YZ Yang, ...
Laboratory investigation 82 (3), 273-283, 2002
3402002
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
J Alber, S Alladi, HJ Bae, DA Barton, LA Beckett, JM Bell, SE Berman, ...
Alzheimer's & Dementia: Translational Research & Clinical Interventions 5 …, 2019
3332019
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
E Hermel, J Gafni, SS Propp, BR Leavitt, CL Wellington, JE Young, ...
Cell Death & Differentiation 11 (4), 424-438, 2004
3042004
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
V Hirsch-Reinshagen, LF Maia, BL Burgess, JF Blain, KE Naus, ...
Journal of Biological Chemistry 280 (52), 43243-43256, 2005
2862005
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
JA Parker, JB Connolly, C Wellington, M Hayden, J Dausset, C Neri
Proceedings of the National Academy of Sciences 98 (23), 13318-13323, 2001
2852001
24 (S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux
K Abildayeva, PJ Jansen, V Hirsch-Reinshagen, VW Bloks, AHF Bakker, ...
Journal of biological chemistry 281 (18), 12799-12808, 2006
2822006
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