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Guillaume MEDARD
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The target landscape of clinical kinase drugs
S Klaeger, S Heinzlmeir, M Wilhelm, H Polzer, B Vick, PA Koenig, ...
Science 358 (6367), eaan4368, 2017
7642017
K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria
CJ Groß, R Mishra, KS Schneider, G Médard, J Wettmarshausen, ...
Immunity 45 (4), 761-773, 2016
4362016
The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity
KS Schneider, CJ Groß, RF Dreier, BS Saller, R Mishra, O Gorka, R Heilig, ...
Cell reports 21 (13), 3846-3859, 2017
2582017
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments
H Hahne, F Pachl, B Ruprecht, SK Maier, S Klaeger, D Helm, G Médard, ...
Nature methods 10 (10), 989-991, 2013
2512013
Optimized chemical proteomics assay for kinase inhibitor profiling
G Médard, F Pachl, B Ruprecht, S Klaeger, S Heinzlmeir, D Helm, H Qiao, ...
Journal of proteome research 14 (3), 1574-1586, 2015
1402015
Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns
B Ruprecht, H Koch, G Medard, M Mundt, B Kuster, S Lemeer
Molecular & Cellular Proteomics 14 (1), 205-215, 2015
1342015
Systematic identification of MCU modulators by orthogonal interspecies chemical screening
DM Arduino, J Wettmarshausen, H Vais, P Navas-Navarro, Y Cheng, ...
Molecular cell 67 (4), 711-723. e7, 2017
1152017
N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu
L Jiang, B Zhang, G Médard, AP Seitsonen, F Haag, F Allegretti, ...
Chemical Science 8 (12), 8301-8308, 2017
982017
Chemical proteomics reveals ferrochelatase as a common off-target of kinase inhibitors
S Klaeger, B Gohlke, J Perrin, V Gupta, S Heinzlmeir, D Helm, H Qiao, ...
ACS chemical biology 11 (5), 1245-1254, 2016
982016
ProteomeTools: Systematic characterization of 21 post-translational protein modifications by liquid chromatography tandem mass spectrometry (LC-MS/MS) using synthetic peptides
DP Zolg, M Wilhelm, T Schmidt, G Médard, J Zerweck, T Knaute, ...
Molecular & Cellular Proteomics 17 (9), 1850-1863, 2018
872018
Chemical proteomics uncovers EPHA2 as a mechanism of acquired resistance to small molecule EGFR kinase inhibition
H Koch, MEDC Busto, K Kramer, G Médard, B Kuster
Journal of proteome research 14 (6), 2617-2625, 2015
612015
Label-free quantitative proteome analysis of the surface-bound salivary pellicle
J Delius, S Trautmann, G Médard, B Kuster, M Hannig, T Hofmann
Colloids and Surfaces B: Biointerfaces 152, 68-76, 2017
572017
Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs
S Heinzlmeir, D Kudlinzki, S Sreeramulu, S Klaeger, SL Gande, V Linhard, ...
ACS chemical biology 11 (12), 3400-3411, 2016
552016
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
S Lechner, MIP Malgapo, C Grätz, RR Steimbach, A Baron, P Rüther, ...
Nature chemical biology 18 (8), 812-820, 2022
512022
Evaluation of kinase activity profiling using chemical proteomics
B Ruprecht, J Zecha, S Heinzlmeir, G Medard, S Lemeer, B Kuster
ACS chemical biology 10 (12), 2743-2752, 2015
422015
Characterization of a chemical affinity probe targeting Akt kinases
F Pachl, P Plattner, B Ruprecht, G Medard, N Sewald, B Kuster
Journal of Proteome Research 12 (8), 3792-3800, 2013
402013
Targeted diazotransfer reagents enable selective modification of proteins with azides
J Lohse, LJYM Swier, RC Oudshoorn, G Médard, B Kuster, DJ Slotboom, ...
Bioconjugate Chemistry 28 (4), 913-917, 2017
362017
Salivary proteome patterns affecting human salt taste sensitivity
T Stolle, F Grondinger, A Dunkel, C Meng, G Médard, B Kuster, ...
Journal of agricultural and food chemistry 65 (42), 9275-9286, 2017
322017
Decrypting drug actions and protein modifications by dose-and time-resolved proteomics
J Zecha, FP Bayer, S Wiechmann, J Woortman, N Berner, J Müller, ...
Science 380 (6640), 93-101, 2023
312023
Effect of astringent stimuli on salivary protein interactions elucidated by complementary proteomics approaches
J Delius, G Médard, B Kuster, T Hofmann
Journal of agricultural and food chemistry 65 (10), 2147-2154, 2017
292017
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