Dominic Helm
Dominic Helm
Proteomics Core Facility, DKFZ
Verified email at
Cited by
Cited by
The target landscape of clinical kinase drugs
S Klaeger, S Heinzlmeir, M Wilhelm, H Polzer, B Vick, PA Koenig, ...
Science 358 (6367), eaan4368, 2017
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments
H Hahne, F Pachl, B Ruprecht, SK Maier, S Klaeger, D Helm, G Médard, ...
Nature methods 10 (10), 989-991, 2013
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice
A Kindt, G Liebisch, T Clavel, D Haller, G Hörmannsperger, H Yoon, ...
Nature communications 9 (1), 3760, 2018
Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP
S Sridharan, N Kurzawa, T Werner, I Guenthner, D Helm, W Huber, ...
Nature communications 10 (1), 1155, 2019
Pervasive protein thermal stability variation during the cell cycle
I Becher, A Andrés-Pons, N Romanov, F Stein, M Schramm, F Baudin, ...
Cell 173 (6), 1495-1507. e18, 2018
Proteome wide purification and identification of O-GlcNAc modified proteins using Click chemistry and mass spectrometry
H Hahne, N Sobotzki, T Nyberg, D Helm, VS Borodkin, DM van Aalten, ...
Journal of proteome research, 2013
Thermal proteome profiling for interrogating protein interactions
A Mateus, N Kurzawa, I Becher, S Sridharan, D Helm, F Stein, A Typas, ...
Molecular systems biology 16 (3), e9232, 2020
Thermal proteome profiling in bacteria: probing protein state in vivo
A Mateus, J Bobonis, N Kurzawa, F Stein, D Helm, J Hevler, A Typas, ...
Molecular systems biology 14 (7), e8242, 2018
Optimized chemical proteomics assay for kinase inhibitor profiling
G Médard, F Pachl, B Ruprecht, S Klaeger, S Heinzlmeir, D Helm, H Qiao, ...
Journal of proteome research 14 (3), 1574-1586, 2015
Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
D Helm, JPC Vissers, CJ Hughes, H Hahne, B Ruprecht, F Pachl, A Grzyb, ...
Molecular & Cellular Proteomics 13 (12), 3709-3715, 2014
moCluster: identifying joint patterns across multiple omics data sets
C Meng, D Helm, M Frejno, B Kuster
Journal of proteome research 15 (3), 755-765, 2016
Chemical proteomics reveals ferrochelatase as a common off-target of kinase inhibitors
S Klaeger, B Gohlke, J Perrin, V Gupta, S Heinzlmeir, D Helm, H Qiao, ...
ACS chemical biology 11 (5), 1245-1254, 2016
The functional proteome landscape of Escherichia coli
A Mateus, J Hevler, J Bobonis, N Kurzawa, M Shah, K Mitosch, ...
Nature 588 (7838), 473-478, 2020
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver
D Inverso, J Shi, KH Lee, M Jakab, S Ben-Moshe, SR Kulkarni, ...
Developmental cell 56 (11), 1677-1693. e10, 2021
The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range
H Girstmair, F Tippel, A Lopez, K Tych, F Stein, P Haberkant, ...
Nature communications 10 (1), 3626, 2019
Proteome activity landscapes of tumor cell lines determine drug responses
M Frejno, C Meng, B Ruprecht, T Oellerich, S Scheich, K Kleigrewe, ...
Nature communications 11 (1), 3639, 2020
Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs
S Heinzlmeir, D Kudlinzki, S Sreeramulu, S Klaeger, SL Gande, V Linhard, ...
ACS chemical biology 11 (12), 3400-3411, 2016
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
E Ratto, SR Chowdhury, NS Siefert, M Schneider, M Wittmann, D Helm, ...
Nature Communications 13 (1), 4848, 2022
Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins
C Pechincha, S Groessl, R Kalis, M de Almeida, A Zanotti, M Wittmann, ...
Science 378 (6615), eabn5637, 2022
Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
B Hoermann, T Kokot, D Helm, S Heinzlmeir, JE Chojnacki, T Schubert, ...
Nature Communications 11 (1), 3583, 2020
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Articles 1–20