Po-Chao Wen
Po-Chao Wen
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Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target
AKS Camara, YF Zhou, PC Wen, E Tajkhorshid, WM Kwok
Frontiers in physiology 8, 460, 2017
Molecular dynamics simulations of membrane channels and transporters
F Khalili-Araghi, J Gumbart, PC Wen, M Sotomayor, E Tajkhorshid, ...
Current opinion in structural biology 19 (2), 128-137, 2009
Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport
JA Coleman, D Yang, Z Zhao, PC Wen, C Yoshioka, E Tajkhorshid, ...
Nature 569 (7754), 141-145, 2019
Structural and functional diversity calls for a new classification of ABC transporters
C Thomas, SG Aller, K Beis, EP Carpenter, G Chang, L Chen, E Dassa, ...
FEBS letters 594 (23), 3767-3775, 2020
On the origin of large flexibility of P-glycoprotein in the inward-facing state
PC Wen, B Verhalen, S Wilkens, HS Mchaourab, E Tajkhorshid
Journal of Biological Chemistry 288 (26), 19211-19220, 2013
Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter
S Mishra, B Verhalen, RA Stein, PC Wen, E Tajkhorshid, HS Mchaourab
Elife 3, e02740, 2014
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer
J Seong, M Ouyang, T Kim, J Sun, PC Wen, S Lu, Y Zhuo, NM Llewellyn, ...
Nature communications 2 (1), 406, 2011
Transient formation of water-conducting states in membrane transporters
J Li, SA Shaikh, G Enkavi, PC Wen, Z Huang, E Tajkhorshid
Proceedings of the National Academy of Sciences 110 (19), 7696-7701, 2013
Dimer opening of the nucleotide binding domains of ABC transporters after ATP hydrolysis
PC Wen, E Tajkhorshid
Biophysical journal 95 (11), 5100-5110, 2008
Conformational coupling of the nucleotide-binding and the transmembrane domains in ABC transporters
PC Wen, E Tajkhorshid
Biophysical journal 101 (3), 680-690, 2011
Visualizing functional motions of membrane transporters with molecular dynamics simulations
SA Shaikh, J Li, G Enkavi, PC Wen, Z Huang, E Tajkhorshid
Biochemistry 52 (4), 569-587, 2013
Computational characterization of structural dynamics underlying function in active membrane transporters
J Li, PC Wen, M Moradi, E Tajkhorshid
Current opinion in structural biology 31, 96-105, 2015
Structural insights into the lipid A transport pathway in MsbA
PS Padayatti, SC Lee, RL Stanfield, PC Wen, E Tajkhorshid, IA Wilson, ...
Structure 27 (7), 1114-1123. e3, 2019
Molecular mechanisms of active transport across the cellular membrane
PC Wen, Z Huang, G Enkavi, E Tajkhorshid
The cellular membrane as a mediator for small molecule interaction with membrane proteins
CG Mayne, MJ Arcario, P Mahinthichaichan, JL Baylon, JV Vermaas, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (10), 2290-2304, 2016
Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
N Haloi, PC Wen, Q Cheng, M Yang, G Natarajan, AKS Camara, ...
Communications biology 4 (1), 667, 2021
Probing key elements of teixobactin–lipid II interactions in membranes
PC Wen, JM Vanegas, SB Rempe, E Tajkhorshid
Chemical Science 9 (34), 6997-7008, 2018
Microscopic view of lipids and their diverse biological functions
PC Wen, P Mahinthichaichan, N Trebesch, T Jiang, Z Zhao, E Shinn, ...
Current opinion in structural biology 51, 177-186, 2018
Computational dissection of membrane transport at a microscopic level
T Jiang, PC Wen, N Trebesch, Z Zhao, S Pant, K Kapoor, M Shekhar, ...
Trends in biochemical sciences 45 (3), 202-216, 2020
Role of internal loop dynamics in antibiotic permeability of outer membrane porins
AK Vasan, N Haloi, RJ Ulrich, ME Metcalf, PC Wen, WW Metcalf, ...
Proceedings of the National Academy of Sciences 119 (8), e2117009119, 2022
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