|Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins|
KM Pan, M Baldwin, J Nguyen, M Gasset, ANA Serban, D Groth, ...
Proceedings of the National Academy of Sciences 90 (23), 10962-10966, 1993
|Eight prion strains have PrP Sc molecules with different conformations|
J Safar, H Wille, V Itri, D Groth, H Serban, M Torchia, FE Cohen, ...
Nature medicine 4 (10), 1157-1165, 1998
|An evolutionary trace method defines binding surfaces common to protein families|
O Lichtarge, HR Bourne, FE Cohen
Journal of molecular biology 257 (2), 342-358, 1996
|Synthetic mammalian prions|
G Legname, IV Baskakov, HOB Nguyen, D Riesner, FE Cohen, ...
Science 305 (5684), 673-676, 2004
|Prion protein biology|
SB Prusiner, MR Scott, SJ DeArmond, FE Cohen
cell 93 (3), 337-348, 1998
|Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein|
GC Telling, M Scott, J Mastrianni, R Gabizon, M Torchia, FE Cohen, ...
Cell 83 (1), 79-90, 1995
|Bayesian statistical analysis of protein side‐chain rotamer preferences|
RL Dunbrack Jr, FE Cohen
Protein Science 6 (8), 1661-1681, 1997
|Therapeutic approaches to protein-misfolding diseases|
FE Cohen, JW Kelly
Nature 426 (6968), 905-909, 2003
|Improvements in protein secondary structure prediction by an enhanced neural network|
DG Kneller, FE Cohen, R Langridge
Journal of molecular biology 214 (1), 171-182, 1990
|Structure of the recombinant full-length hamster prion protein PrP (29–231): the N terminus is highly flexible|
DG Donne, JH Viles, D Groth, I Mehlhorn, TL James, FE Cohen, ...
Proceedings of the National Academy of Sciences 94 (25), 13452-13457, 1997
|Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease|
C Korth, BCH May, FE Cohen, SB Prusiner
Proceedings of the National Academy of Sciences 98 (17), 9836-9841, 2001
|Evidence for assembly of prions with left-handed β-helices into trimers|
C Govaerts, H Wille, SB Prusiner, FE Cohen
Proceedings of the National Academy of Sciences 101 (22), 8342-8347, 2004
|Structural clues to prion replication|
FE Cohen, KM Pan, Z Huang, M Baldwin, RJ Fletterick, SB Prusiner
Science 264 (5158), 530-532, 1994
|Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool|
MJ Bower, FE Cohen, RL Dunbrack Jr
Journal of molecular biology 267 (5), 1268-1282, 1997
|Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel|
RC Moore, IY Lee, GL Silverman, PM Harrison, R Strome, C Heinrich, ...
Journal of molecular biology 292 (4), 797-817, 1999
|Pathologic conformations of prion proteins|
FE Cohen, SB Prusiner
Annual review of biochemistry 67 (1), 793-819, 1998
|Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation|
K Kaneko, L Zulianello, M Scott, CM Cooper, AC Wallace, TL James, ...
Proceedings of the national academy of sciences 94 (19), 10069-10074, 1997
|Copper binding to the prion protein: structural implications of four identical cooperative binding sites|
JH Viles, FE Cohen, SB Prusiner, DB Goodin, PE Wright, HJ Dyson
Proceedings of the National Academy of Sciences 96 (5), 2042-2047, 1999
|Prion protein selectively binds copper (II) ions|
J Stöckel, J Safar, AC Wallace, FE Cohen, SB Prusiner
Biochemistry 37 (20), 7185-7193, 1998
|Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform|
TL James, H Liu, NB Ulyanov, S Farr-Jones, H Zhang, DG Donne, ...
Proceedings of the National Academy of Sciences 94 (19), 10086-10091, 1997