Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice CJ Cummings, Y Sun, P Opal, B Antalffy, R Mestril, HT Orr, WH Dillmann, ... Human molecular genetics 10 (14), 1511-1518, 2001 | 603 | 2001 |
The function of intermediate filaments in cell shape and cytoskeletal integrity. RD Goldman, S Khuon, YH Chou, P Opal, PM Steinert The Journal of cell biology 134 (4), 971-983, 1996 | 497 | 1996 |
Intermediate filament dynamics JE Eriksson, P Opal, RD Goldman Current Opinion in Cell Biology 4 (1), 99-104, 1992 | 181 | 1992 |
Intrafamilial phenotypic variability of the DYT1 dystonia: From asymptomatic TOR1A gene carrier status to dystonic storm P Opal, R Tintner, J Jankovic, J Leung, XO Breakefield, J Friedman, ... Movement disorders: official journal of the Movement Disorder Society 17 (2 …, 2002 | 147 | 2002 |
Giant axonal neuropathy–associated gigaxonin mutations impair intermediate filament protein degradation S Mahammad, SNP Murthy, A Didonna, B Grin, E Israeli, R Perrot, ... The Journal of clinical investigation 123 (5), 1964-1975, 2013 | 118 | 2013 |
The promise and perils of HDAC inhibitors in neurodegeneration A Didonna, P Opal Annals of clinical and translational neurology 2 (1), 79-101, 2015 | 109 | 2015 |
Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability JM Dell'Orco, AH Wasserman, R Chopra, MAC Ingram, YS Hu, V Singh, ... Journal of Neuroscience 35 (32), 11292-11307, 2015 | 104 | 2015 |
Paraneoplastic cerebellar degeneration with anti‐Yo antibodies–a review A Venkatraman, P Opal Annals of clinical and translational neurology 3 (8), 655-663, 2016 | 102 | 2016 |
Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1 M Cvetanovic, JM Patel, HH Marti, AR Kini, P Opal Nature medicine 17 (11), 1445-1447, 2011 | 98 | 2011 |
Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1 M Cvetanovic, M Ingram, H Orr, P Opal Neuroscience 289, 289-299, 2015 | 94 | 2015 |
The relative roles of specific N-and C-terminal phosphorylation sites in the disassembly of intermediate filament in mitotic BHK-21 cells YH Chou, P Opal, RA Quinlan, RD Goldman Journal of cell science 109 (4), 817-826, 1996 | 93 | 1996 |
The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders A Didonna, P Opal Molecular neurodegeneration 14 (1), 1-10, 2019 | 92 | 2019 |
Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis P Opal, JJ Garcia, F Propst, A Matilla, HT Orr, HY Zoghbi Journal of Biological Chemistry 278 (36), 34691-34699, 2003 | 79 | 2003 |
Alterations in neural intermediate filament organization: functional implications and the induction of pathological changes related to motor neuron disease K Straube-West, PA Loomis, P Opal, RD Goldman Journal of cell science 109 (9), 2319-2329, 1996 | 60 | 1996 |
In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome AG Bassuk, YZ Chen, SD Batish, N Nagan, P Opal, PF Chance, ... Neurogenetics 8, 45-49, 2007 | 58 | 2007 |
The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1 A Venkatraman, YS Hu, A Didonna, M Cvetanovic, A Krbanjevic, ... Human molecular genetics 23 (14), 3733-3745, 2014 | 52 | 2014 |
Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1 CR Edamakanti, J Do, A Didonna, M Martina, P Opal The Journal of clinical investigation 128 (6), 2252-2265, 2018 | 50 | 2018 |
The role of LANP and ataxin 1 in E4F‐mediated transcriptional repression M Cvetanovic, RJ Rooney, JJ Garcia, N Toporovskaya, HY Zoghbi, P Opal EMBO reports 8 (7), 671-677, 2007 | 49 | 2007 |
Generation and characterization of LANP/pp32 null mice P Opal, JJ Garcia, AE McCall, B Xu, EJ Weeber, JD Sweatt, HT Orr, ... Molecular and cellular biology 24 (8), 3140-3149, 2004 | 46 | 2004 |
The role of chaperones in polyglutamine disease P Opal, HY Zoghbi Trends in molecular medicine 8 (5), 232-236, 2002 | 42 | 2002 |