| Elevated levels of interleukin-6 in unstable angina LM Biasucci, A Vitelli, G Liuzzo, S Altamura, G Caligiuri, C Monaco, ... Circulation 94 (5), 874-877, 1996 | 1126 | 1996 |
| Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina G Liuzzo, A Buffon, LM Biasucci, JR Gallimore, G Caligiuri, A Vitelli, ... Circulation 98 (22), 2370-2376, 1998 | 481 | 1998 |
| Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro G Migliaccio, JE Tomassini, SS Carroll, L Tomei, S Altamura, B Bhat, ... Journal of Biological Chemistry 278 (49), 49164-49170, 2003 | 373 | 2003 |
| Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase R De Francesco, L Tomei, S Altamura, V Summa, G Migliaccio Antiviral research 58 (1), 1-16, 2003 | 360 | 2003 |
| Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in … P Jones, S Altamura, J Boueres, F Ferrigno, M Fonsi, C Giomini, ... Journal of medicinal chemistry 52 (22), 7170-7185, 2009 | 357 | 2009 |
| Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products P Ingallinella, S Altamura, E Bianchi, M Taliani, R Ingenito, R Cortese, ... Biochemistry 37 (25), 8906-8914, 1998 | 250 | 1998 |
| Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase L Tomei, S Altamura, L Bartholomew, A Biroccio, A Ceccacci, L Pacini, ... Journal of virology 77 (24), 13225-13231, 2003 | 241 | 2003 |
| Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ... Journal of Biological Chemistry 280 (33), 29765-29770, 2005 | 205 | 2005 |
| Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture P Neddermann, M Quintavalle, C Di Pietro, A Clementi, M Cerretani, ... Journal of virology 78 (23), 13306-13314, 2004 | 202 | 2004 |
| A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ... Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002 | 194 | 2002 |
| Discovery of α, γ-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase V Summa, A Petrocchi, P Pace, VG Matassa, R De Francesco, S Altamura, ... Journal of medicinal chemistry 47 (1), 14-17, 2004 | 176 | 2004 |
| Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides L Tomei, S Altamura, L Bartholomew, M Bisbocci, C Bailey, M Bosserman, ... Journal of virology 78 (2), 938-946, 2004 | 172 | 2004 |
| Rational design of a receptor super‐antagonist of human interleukin‐6. R Savino, L Ciapponi, A Lahm, A Demartis, A Cabibbo, C Toniatti, ... The EMBO Journal 13 (24), 5863-5870, 1994 | 170 | 1994 |
| Generation of interleukin‐6 receptor antagonists by molecular‐modeling guided mutagenesis of residues important for gp130 activation. R Savino, A Lahm, AL Salvati, L Ciapponi, E Sporeno, S Altamura, ... The EMBO journal 13 (6), 1357-1367, 1994 | 168 | 1994 |
| In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ... Journal of virology 77 (6), 3669-3679, 2003 | 161 | 2003 |
| 2-(2-Thienyl)-5, 6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis U Koch, B Attenni, S Malancona, S Colarusso, I Conte, M Di Filippo, ... Journal of Medicinal Chemistry 49 (5), 1693-1705, 2006 | 157 | 2006 |
| Affinity selection of a camelized V (H) domain antibody inhibitor of hepatitis C virus NS3 protease. F Martin, C Volpari, C Steinkuhler, N Dimasi, M Brunetti, G Biasiol, ... Protein Engineering 10 (5), 607-614, 1997 | 142 | 1997 |
| HCV NS5b RNA-dependent RNA polymerase inhibitors: from α, γ-diketoacids to 4, 5-dihydroxypyrimidine-or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis V Summa, A Petrocchi, VG Matassa, M Taliani, R Laufer, R De Francesco, ... Journal of medicinal chemistry 47 (22), 5336-5339, 2004 | 137 | 2004 |
| Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase S Harper, S Avolio, B Pacini, M Di Filippo, S Altamura, L Tomei, ... Journal of medicinal chemistry 48 (14), 4547-4557, 2005 | 133 | 2005 |
| Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases P Jones, S Altamura, R De Francesco, P Gallinari, A Lahm, ... Bioorganic & medicinal chemistry letters 18 (6), 1814-1819, 2008 | 123 | 2008 |
raffaele de francescoIstituto Nazionale Genetica Molecolare - INGM and DiSFeB, University of Milan, ItalyVerified email at ingm.org
