A. S. Lewin

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Cristhian IldefonsoResearch Assistant Professor , University of FloridaVerified email at ufl.edu
Sanford L. BoyePowell Gene Therapy Center, Department of Pediatrics, University of FloridaVerified email at ufl.edu
Manas R. Biswal, Ph.D.Associate Professor, University of South Florida, Tampa, FL, USA.Verified email at usf.edu
Artur CideciyanResearch Professor of Ophthalmology, University of PennsylvaniaVerified email at mail.med.upenn.edu
Samuel G. JacobsonProfessor of Ophthalmology, University of PennsylvaniaVerified email at mail.med.upenn.edu
maria grantProfessor of Ophthalmology, Indiana UniversityVerified email at iupui.edu
Chulbul M. AhmedUniversity of FloridaVerified email at ufl.edu
William BeltranProfessor of Ophthalmology- University of PennsylvaniaVerified email at vet.upenn.edu
Oleg GorbatyukResearch Associate Professor, University of Alabama at BirminghamVerified email at uab.edu
Shannon BoyeAssociate Professor, University of FloridaVerified email at ufl.edu
Fredric ManfredssonBarrow Neurological InstituteVerified email at barrowneuro.org
Vittorio porciattiProfessor, Bascom Palmer Eye Institute, Miami, FLVerified email at med.miami.edu
Richard I. MorimotoBill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, NorthwesternVerified email at northwestern.edu
Barry J. ByrneUniversity of FloridaVerified email at ufl.edu
Valerio CarelliDepartment of Biomedical and Neuromotor Sciences, University of BolognaVerified email at unibo.it
Mohan K RaizadaDistinguished Professor of Physiology, University of FloridaVerified email at ufl.edu
Sriniwas SriramPostdoctoral fellow, Harvard Medical SchoolVerified email at meei.harvard.edu
CORINNA BURGERAssociate Professor in Neurology, University of WisconsinVerified email at wisc.edu
Catherine Bowes RickmanProfessor of Ophthalmology and of Cell BiologyVerified email at duke.edu
Sergio CaballeroUniversity of FloridaVerified email at ufl.edu

A. S. Lewin

University of Florida

Verified email at ufl.edu - Homepage

mitochondria gene therapy retinal degeneration age related macular degeneration cardivascular disease


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Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa AS Lewin, KA Drenser, WW Hauswirth, S Nishikawa, D Yasumura, ... Nature medicine 4 (8), 967-971, 1998	519	1998
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors H Petrs-Silva, A Dinculescu, Q Li, SH Min, V Chiodo, JJ Pang, L Zhong, ... Molecular therapy 17 (3), 463-471, 2009	494	2009
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD SK Mitter, C Song, X Qi, H Mao, H Rao, D Akin, A Lewin, M Grant, ... Autophagy 10 (11), 1989-2005, 2014	463	2014
A comprehensive review of retinal gene therapy SE Boye, SL Boye, AS Lewin, WW Hauswirth Molecular therapy 21 (3), 509-519, 2013	346	2013
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice E Rodriguez-Lebron, EM Denovan-Wright, K Nash, AS Lewin, RJ Mandel Molecular therapy 12 (4), 618-633, 2005	332	2005
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa WA Beltran, AV Cideciyan, AS Lewin, S Iwabe, H Khanna, A Sumaroka, ... Proceedings of the National Academy of Sciences 109 (6), 2132-2137, 2012	322	2012
Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy J Guy, X Qi, F Pallotti, EA Schon, G Manfredi, V Carelli, A Martinuzzi, ... Annals of Neurology: Official Journal of the American Neurological …, 2002	315	2002
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina H Petrs-Silva, A Dinculescu, Q Li, WT Deng, J Pang, SH Min, V Chiodo, ... Molecular Therapy 19 (2), 293-301, 2011	309	2011
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 MS Gorbatyuk, T Knox, MM LaVail, OS Gorbatyuk, SM Noorwez, ... Proceedings of the National Academy of Sciences 107 (13), 5961-5966, 2010	301	2010
SOD2 knockdown mouse model of early AMD V Justilien, JJ Pang, K Renganathan, X Zhan, JW Crabb, SR Kim, ... Investigative ophthalmology & visual science 48 (10), 4407-4420, 2007	279	2007
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy MM LaVail, D Yasumura, MT Matthes, KA Drenser, JG Flannery, AS Lewin, ... Proceedings of the National Academy of Sciences 97 (21), 11488-11493, 2000	266	2000
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ... Molecular Therapy 18 (8), 1450-1457, 2010	243	2010
[48] Production and purification of recombinant adeno-associated virus WW Hauswirth, AS Lewin, S Zolotukhin, N Muzyczka Methods in enzymology 316, 743-761, 2000	210	2000
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease MS Gorbatyuk, A Shabashvili, W Chen, C Meyers, LF Sullivan, M Salganik, ... Molecular Therapy 20 (7), 1327-1337, 2012	205	2012
Ribozyme gene therapy: applications for molecular medicine AS Lewin, WW Hauswirth Trends in molecular medicine 7 (5), 221-228, 2001	204	2001
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy A Verma, Z Shan, B Lei, L Yuan, X Liu, T Nakagawa, MB Grant, AS Lewin, ... Molecular therapy 20 (1), 28-36, 2012	202	2012
Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors EE Brown, AJ DeWeerd, CJ Ildefonso, AS Lewin, JD Ash Redox biology 24, 101201, 2019	196	2019
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model H Yu, RD Koilkonda, TH Chou, V Porciatti, SS Ozdemir, V Chiodo, ... Proceedings of the National Academy of Sciences 109 (20), E1238-E1247, 2012	188	2012
Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis X Qi, AS Lewin, L Sun, WW Hauswirth, J Guy Journal of Biological Chemistry 281 (42), 31950-31962, 2006	171	2006
Citrate Synthase Encoded by the CIT2 Gene of Saccharomyces cerevisiae Is Peroxisomal AS Lewin, V Hines, GM Small Molecular and Cellular Biology 10 (4), 1399-1405, 1990	153	1990

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