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Igor Dikiy, PhD
Igor Dikiy, PhD
Protein Biochemistry, Regeneron Pharmaceuticals
Verified email at regeneron.com
Title
Cited by
Cited by
Year
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear …
MB Fares, N Ait-Bouziad, I Dikiy, MK Mbefo, A Jovičić, A Kiely, JL Holton, ...
Human molecular genetics 23 (17), 4491-4509, 2014
2612014
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
AL Mahul-Mellier, B Fauvet, A Gysbers, I Dikiy, A Oueslati, S Georgeon, ...
Human molecular genetics 23 (11), 2858-2879, 2014
2332014
Folding and misfolding of alpha-synuclein on membranes
I Dikiy, D Eliezer
Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (4), 1013-1018, 2012
2222012
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity
O Khalaf, B Fauvet, A Oueslati, I Dikiy, AL Mahul-Mellier, FS Ruggeri, ...
Journal of Biological Chemistry 289 (32), 21856-21876, 2014
2132014
N-terminal acetylation stabilizes N-terminal helicity in lipid-and micelle-bound α-synuclein and increases its affinity for physiological membranes
I Dikiy, D Eliezer
Journal of Biological Chemistry 289 (6), 3652-3665, 2014
2012014
Characterization of semisynthetic and naturally nα-acetylated α-synuclein in vitro and in intact cells implications for aggregation and cellular properties of α-synuclein
B Fauvet, MB Fares, F Samuel, I Dikiy, A Tandon, D Eliezer, HA Lashuel
Journal of Biological Chemistry 287 (34), 28243-28262, 2012
1902012
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125
M Hejjaoui, S Butterfield, B Fauvet, F Vercruysse, J Cui, I Dikiy, M Prudent, ...
Journal of the American Chemical Society 134 (11), 5196-5210, 2012
1262012
Ligand modulation of sidechain dynamics in a wild-type human GPCR
LD Clark, I Dikiy, K Chapman, KE Rödström, J Aramini, MV LeVine, ...
eLife 6, e28505, 2017
872017
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by …
I Dikiy, B Fauvet, A Jovicic, AL Mahul-Mellier, C Desobry, F El-Turk, ...
ACS chemical biology 11 (9), 2428-2437, 2016
692016
An experimental and computational investigation of spontaneous lasso formation in microcin J25
AL Ferguson, S Zhang, I Dikiy, AZ Panagiotopoulos, PG Debenedetti, ...
Biophysical journal 99 (9), 3056-3065, 2010
612010
STARD4 membrane interactions and sterol binding
DB Iaea, I Dikiy, I Kiburu, D Eliezer, FR Maxfield
Biochemistry 54 (30), 4623-4636, 2015
562015
On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies
L Clark, I Dikiy, DM Rosenbaum, KH Gardner
Journal of biomolecular NMR 71 (4), 203-211, 2018
402018
Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346
I Dikiy, UR Edupuganti, RR Abzalimov, PP Borbat, M Srivastava, JH Freed, ...
Proceedings of the National Academy of Sciences 116 (11), 4963-4972, 2019
212019
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles
DM Kim, I Dikiy, V Upadhyay, DJ Posson, D Eliezer, CM Nimigean
The Journal of General Physiology 148 (2), 119-132, 2016
212016
Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.
I Dikiy, LD Clark, KH Gardner, DM Rosenbaum
Methods in enzymology 614, 37-65, 2019
92019
1H, 13C, and 15N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4)
I Dikiy, TF Ramlall, D Eliezer
Biomolecular NMR assignments 7 (2), 245-248, 2013
32013
Diversity of function and higher-order structure within HWE sensor histidine kinases
I Dikiy, D Swingle, K Toy, UR Edupuganti, G Rivera-Cancel, KH Gardner
Journal of Biological Chemistry, 104934, 2023
22023
Fragile protein folds: Sequence and environmental factors affecting the equilibrium of two interconverting, stably folded protein conformations
X Xu, I Dikiy, MR Evans, LP Marcelino, KH Gardner
Magnetic Resonance 2 (1), 63-76, 2021
12021
C-Abl Phosphorylates Alpha-synuclein And Regulates Its Degradation, Implication For Alpha-synuclein Clearance And Contribution To The Pathogenesis Of Parkinson's Disease
A Mahul, B Fauvet, A Gysbers, I Dikiy, A Oueslati, S Georgeon, ...
Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1 …, 2014
12014
Nmr methods for antibody higher order structure comparability
I Dikiy, W Matousek
US Patent App. 17/851,845, 2022
2022
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