Eric D Brown
Eric D Brown
Professor of Biochemistry, McMaster University
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Cited by
Cited by
Antibiotic resistance—the need for global solutions
R Laxminarayan, A Duse, C Wattal, AKM Zaidi, HFL Wertheim, ...
The Lancet infectious diseases 13 (12), 1057-1098, 2013
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
RA Alm, LSL Ling, DT Moir, BL King, ED Brown, PC Doig, DR Smith, ...
Nature 397 (6715), 176-180, 1999
Antibacterial drug discovery in the resistance era
ED Brown, GD Wright
Nature 529 (7586), 336-343, 2016
A deep learning approach to antibiotic discovery
JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, ...
Cell 180 (4), 688-702. e13, 2020
A comprehensive, CRISPR-based functional analysis of essential genes in bacteria
JM Peters, A Colavin, H Shi, TL Czarny, MH Larson, S Wong, JS Hawkins, ...
Cell 165 (6), 1493-1506, 2016
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells
E Sachlos, RM Risueño, S Laronde, Z Shapovalova, JH Lee, J Russell, ...
Cell 149 (6), 1284-1297, 2012
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
L Ejim, MA Farha, SB Falconer, J Wildenhain, BK Coombes, M Tyers, ...
Nature chemical biology 7 (6), 348-350, 2011
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
BP Alcock, W Huynh, R Chalil, KW Smith, AR Raphenya, MA Wlodarski, ...
Nucleic acids research 51 (D1), D690-D699, 2023
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli
ED Brown, EI Vivas, CT Walsh, R Kolter
Journal of bacteriology 177 (14), 4194-4197, 1995
Drug repurposing for antimicrobial discovery
MA Farha, ED Brown
Nature microbiology 4 (4), 565-577, 2019
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance
JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ...
Nature microbiology 2 (5), 1-8, 2017
Strategies for target identification of antimicrobial natural products
MA Farha, ED Brown
Natural product reports 33 (5), 668-680, 2016
Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
CR MacNair, JM Stokes, LA Carfrae, AA Fiebig-Comyn, BK Coombes, ...
Nature communications 9 (1), 458, 2018
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase
JE Blanchard, NH Elowe, C Huitema, PD Fortin, JD Cechetto, LD Eltis, ...
Chemistry & biology 11 (10), 1445-1453, 2004
Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus
MA Farha, CP Verschoor, D Bowdish, ED Brown
Chemistry & biology 20 (9), 1168-1178, 2013
Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains
P Doig, BL de Jonge, RA Alm, ED Brown, M Uria-Nickelsen, B Noonan, ...
Microbiology and Molecular Biology Reviews 63 (3), 675-707, 1999
Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams
MA Farha, A Leung, EW Sewell, MA D’Elia, SE Allison, L Ejim, PM Pereira, ...
ACS chemical biology 8 (1), 226-233, 2013
New targets and screening approaches in antimicrobial drug discovery
ED Brown, GD Wright
Chemical reviews 105 (2), 759-774, 2005
Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis
MA D'Elia, KE Millar, TJ Beveridge, ED Brown
Journal of bacteriology 188 (23), 8313-8316, 2006
Lesions in Teichoic Acid Biosynthesis in Staphylococcus aureus Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway
MA D'Elia, MP Pereira, YS Chung, W Zhao, A Chau, TJ Kenney, ...
Journal of bacteriology 188 (12), 4183-4189, 2006
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