Chiara Ambrogio
Chiara Ambrogio
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The anaplastic lymphoma kinase in the pathogenesis of cancer
R Chiarle, C Voena, C Ambrogio, R Piva, G Inghirami
Nature Reviews Cancer 8 (1), 11-23, 2008
KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS
C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, ...
Cell 172 (4), 857-868. e15, 2018
Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology
RB Blasco, E Karaca, C Ambrogio, TC Cheong, E Karayol, VG Minero, ...
Cell reports 9 (4), 1219-1227, 2014
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma
C Ambrogio, G Gomez-Lopez, M Falcone, A Vidal, E Nadal, N Crosetto, ...
Nature medicine 22 (3), 270-277, 2016
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas
R Piva, R Chiarle, AD Manazza, R Taulli, W Simmons, C Ambrogio, ...
Blood 107 (2), 689-697, 2006
Potent and selective covalent quinazoline inhibitors of KRAS G12C
M Zeng, J Lu, L Li, F Feru, C Quan, TW Gero, SB Ficarro, Y Xiong, ...
Cell chemical biology 24 (8), 1005-1016. e3, 2017
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling
P Gonzalo, MC Guadamillas, MV Hernández-Riquer, Á Pollán, ...
Developmental cell 18 (1), 77-89, 2010
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
R Chiarle, C Martinengo, C Mastini, C Ambrogio, V D'escamard, G Forni, ...
Nature medicine 14 (6), 676-680, 2008
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
M Compagno, Q Wang, C Pighi, TC Cheong, FL Meng, T Poggio, ...
Nature 542 (7642), 489-493, 2017
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration
C Voena, C Conte, C Ambrogio, E Boeri Erba, F Boccalatte, S Mohammed, ...
Cancer research 67 (9), 4278-4286, 2007
NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
C Ambrogio, C Martinengo, C Voena, F Tondat, L Riera, PF di Celle, ...
Cancer research 69 (22), 8611-8619, 2009
Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer
I Dagogo-Jack, P Martinez, BY Yeap, C Ambrogio, LA Ferris, C Lydon, ...
Clinical Cancer Research 25 (1), 158-165, 2019
A Braf kinase-inactive mutant induces lung adenocarcinoma
P Nieto, C Ambrogio, L Esteban-Burgos, G Gómez-López, MT Blasco, ...
Nature 548 (7666), 239-243, 2017
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase
C Ambrogio, C Voena, AD Manazza, R Piva, L Riera, L Barberis, C Costa, ...
Blood 106 (12), 3907-3916, 2005
Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner
N Crosetto, M Bienko, RG Hibbert, T Perica, C Ambrogio, T Kensche, ...
Journal of Biological Chemistry 283 (50), 35173-35185, 2008
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
AJ Lopez-Contreras, J Specks, JH Barlow, C Ambrogio, C Desler, ...
Genes & development 29 (7), 690-695, 2015
Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma
D Di Paolo, C Ambrogio, F Pastorino, C Brignole, C Martinengo, ...
Molecular Therapy 19 (12), 2201-2212, 2011
Leukocyte transmigration is modulated by chemokine‐mediated PI3Kγ‐dependent phosphorylation of vimentin
L Barberis, C Pasquali, D Bertschy‐Meier, A Cuccurullo, C Costa, ...
European journal of immunology 39 (4), 1136-1146, 2009
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation
C Ambrogio, C Voena, AD Manazza, C Martinengo, C Costa, ...
Cancer research 68 (21), 8899-8907, 2008
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ
C Costa, L Barberis, C Ambrogio, AD Manazza, E Patrucco, O Azzolino, ...
Proceedings of the National Academy of Sciences 104 (36), 14354-14359, 2007
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