Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases DH Kwan, Y Sun, F Schulz, H Hong, B Popovic, JCC Sim-Stark, ... Chemistry & biology 15 (11), 1231-1240, 2008 | 159 | 2008 |
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137 BM Harvey, T Mironenko, Y Sun, H Hong, Z Deng, PF Leadlay, ... Chemistry & biology 14 (6), 703-714, 2007 | 134 | 2007 |
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria H Hong, C Demangel, SJ Pidot, PF Leadlay, T Stinear Natural product reports 25 (3), 447-454, 2008 | 132 | 2008 |
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation L Guenin-Macé, R Veyron-Churlet, MI Thoulouze, G Romet-Lemonne, ... The Journal of clinical investigation 123 (4), 1501-1512, 2013 | 108 | 2013 |
Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs H Hong, E Coutanceau, M Leclerc, L Caleechurn, PF Leadlay, ... PLoS neglected tropical diseases 2 (10), e325, 2008 | 103 | 2008 |
Common Evolutionary Origin for the Unstable Virulence Plasmid pMUM Found in Geographically Diverse Strains of Mycobacterium ulcerans TP Stinear, H Hong, W Frigui, MJ Pryor, R Brosch, T Garnier, PF Leadlay, ... Journal of bacteriology 187 (5), 1668-1676, 2005 | 100 | 2005 |
Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic Y Demydchuk, Y Sun, H Hong, J Staunton, JB Spencer, PF Leadlay ChemBioChem 9 (7), 1136-1145, 2008 | 91 | 2008 |
A late‐stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster ME Yurkovich, PA Tyrakis, H Hong, Y Sun, M Samborskyy, K Kamiya, ... ChemBioChem 13 (1), 66-71, 2012 | 80 | 2012 |
Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea KJ Weissman, H Hong, M Oliynyk, AP Siskos, PF Leadlay ChemBioChem 5 (1), 116-125, 2004 | 78 | 2004 |
Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure L Smith, H Hong, JB Spencer, PF Leadlay ChemBioChem 9 (18), 2967-2975, 2008 | 75 | 2008 |
Glyceryl‐S‐Acyl Carrier Protein as an Intermediate in the Biosynthesis of Tetronate Antibiotics Y Sun, H Hong, F Gillies, JB Spencer, PF Leadlay ChemBioChem 9 (1), 150-156, 2008 | 73 | 2008 |
Fragmentation studies on monensin A and B by accurate‐mass electrospray tandem mass spectrometry NP Lopes, CBW Stark, H Hong, PJ Gates, J Staunton Rapid communications in mass spectrometry 16 (5), 414-420, 2002 | 73 | 2002 |
Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin BM Harvey, H Hong, MA Jones, ZA Hughes‐Thomas, RM Goss, ... ChemBioChem 7 (9), 1435-1442, 2006 | 72 | 2006 |
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones SJ Pidot, H Hong, T Seemann, JL Porter, MJ Yip, A Men, M Johnson, ... BMC genomics 9, 1-15, 2008 | 71 | 2008 |
The fragmentation mechanism of five-membered lactones by electrospray ionisation tandem mass spectrometry AEM Crotti, T Fonseca, H Hong, J Staunton, SE Galembeck, NP Lopes, ... International Journal of Mass Spectrometry 232 (3), 271-276, 2004 | 69 | 2004 |
A common origin for guanidinobutanoate starter units in antifungal natural products. H Hong, T Fill, PF Leadlay Angewandte Chemie 125 (49), 2013 | 66 | 2013 |
Rapamycin biosynthesis: elucidation of gene product function MA Gregory, H Hong, RE Lill, S Gaisser, H Petkovic, L Low, LS Sheehan, ... Organic & biomolecular chemistry 4 (19), 3565-3568, 2006 | 65 | 2006 |
Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus MA Gregory, S Gaisser, RE Lill, H Hong, RM Sheridan, B Wilkinson, ... Angewandte Chemie (International ed. in English) 43 (19), 2551-2553, 2004 | 60 | 2004 |
A Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in … H Hong, JB Spencer, JL Porter, PF Leadlay, T Stinear Chembiochem 6 (4), 643-648, 2005 | 56 | 2005 |
Unusual acetylation–elimination in the formation of tetronate antibiotics C Kanchanabanca, W Tao, H Hong, Y Liu, F Hahn, M Samborskyy, ... Angewandte Chemie 125 (22), 5897-5900, 2013 | 55 | 2013 |