Conor Lynch
Conor Lynch
Prof. of Tumor Biology, Moffitt Cancer Center
Verified email at
Cited by
Cited by
Matrix metalloproteinases in tumor–host cell communication
CC Lynch, LM Matrisian
Differentiation: REVIEW 70 (9‐10), 561-573, 2002
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
CC Lynch, A Hikosaka, HB Acuff, MD Martin, N Kawai, RK Singh, ...
Cancer cell 7 (5), 485-496, 2005
Moving targets: Emerging roles for MMPs in cancer progression and metastasis
G Shay, CC Lynch, B Fingleton
Matrix biology 44, 200-206, 2015
Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion
JH Harmey, CD Bucana, W Lu, AM Byrne, S McDonnell, C Lynch, ...
International journal of cancer 101 (5), 415-422, 2002
Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.
JO McIntyre, B Fingleton, KS Wells, DW Piston, CC Lynch, S Gautam, ...
Biochemical Journal 377 (Pt 3), 617, 2004
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background
MD Martin, KJ Carter, SR Jean-Philippe, M Chang, S Mobashery, ...
Cancer research 68 (15), 6251-6259, 2008
Differential effects between the loss of MMP‐2 and MMP‐9 on structural and tissue‐level properties of bone
JS Nyman, CC Lynch, DS Perrien, S Thiolloy, EC O'Quinn, CA Patil, X Bi, ...
Journal of Bone and Mineral Research 26 (6), 1252-1260, 2011
Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor
JL Halpern, A Kilbarger, CC Lynch
Cancer letters 308 (1), 91-99, 2011
Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis
CC Lynch
Bone 48 (1), 44-53, 2011
Raman and mechanical properties correlate at whole bone-and tissue-levels in a genetic mouse model
X Bi, CA Patil, CC Lynch, GM Pharr, A Mahadevan-Jansen, JS Nyman
Journal of biomechanics 44 (2), 297-303, 2011
An integrated computational model of the bone microenvironment in bone-metastatic prostate cancer
A Araujo, LM Cook, CC Lynch, D Basanta
Cancer research 74 (9), 2391-2401, 2014
Integrating new discoveries into the “vicious cycle” paradigm of prostate to bone metastases
LM Cook, G Shay, A Aruajo, CC Lynch
Cancer and Metastasis Reviews 33, 511-525, 2014
Role of matrix metalloproteinases in normal and disease processes
S McDonnell, M Morgan, C Lynch
Biochemical Society Transactions 27 (4), 734-740, 1999
New approaches to selectively target cancer-associated matrix metalloproteinase activity
M Tauro, J McGuire, CC Lynch
Cancer and metastasis reviews 33, 1043-1057, 2014
Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor
CC Lynch, T Vargo-Gogola, MD Martin, B Fingleton, HC Crawford, ...
Cancer research 67 (14), 6760-6767, 2007
Osteoclast-derived matrix metalloproteinase-9 directly affects angiogenesis in the prostate tumor–bone microenvironment
A Bruni-Cardoso, LC Johnson, RL Vessella, TE Peterson, CC Lynch
Molecular Cancer Research 8 (4), 459-470, 2010
Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis
S Thiolloy, J Halpern, GE Holt, HS Schwartz, GR Mundy, LM Matrisian, ...
Cancer research 69 (16), 6747-6755, 2009
Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities
G Shay, L Hazlehurst, CC Lynch
Journal of Molecular Medicine 94, 21-35, 2016
Cutting to the chase: how matrix metalloproteinase-2 activity controls breast-cancer-to-bone metastasis
M Tauro, CC Lynch
Cancers 10 (6), 185, 2018
Cleavage of E‐cadherin by matrix metalloproteinase‐7 promotes cellular proliferation in nontransformed cell lines via activation of RhoA
CC Lynch, T Vargo-Gogola, LM Matrisian, B Fingleton
Journal of Oncology 2010 (1), 530745, 2010
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