Javier A. Jaimes
Javier A. Jaimes
Senior Research Scientist - University of Massachusetts Medical School
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Coronavirus membrane fusion mechanism offers a potential target for antiviral development
T Tang, M Bidon, JA Jaimes, GR Whittaker, S Daniel
Antiviral research 178, 104792, 2020
Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop
JA Jaimes, NM André, JS Chappie, JK Millet, GR Whittaker
Journal of molecular biology 432 (10), 3309-3325, 2020
Proteolytic cleavage of the SARS-CoV-2 spike protein and the role of the novel S1/S2 site
JA Jaimes, JK Millet, GR Whittaker
IScience 23 (6), 101212, 2020
Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B. 1.1. 7 (Alpha) spike
B Lubinski, MHV Fernandes, L Frazier, T Tang, S Daniel, DG Diel, ...
iScience 25 (1), 103589, 2022
A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses
JA Jaimes, JK Millet, AE Stout, NM André, GR Whittaker
Viruses 12 (1), 83, 2020
Proteolytic activation of SARS-CoV-2 spike at the S1/S2 boundary: potential role of proteases beyond furin
T Tang, JA Jaimes, MK Bidon, MR Straus, S Daniel, GR Whittaker
ACS Infectious Diseases 7 (2), 264-271, 2021
Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit?
AE Stout, NM André, JA Jaimes, JK Millet, GR Whittaker
Veterinary microbiology 247, 108777, 2020
Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function
JA Jaimes, GR Whittaker
Virology 517, 108-121, 2018
Molecular diversity of coronavirus host cell entry receptors
JK Millet, JA Jaimes, GR Whittaker
FEMS microbiology reviews 45 (3), fuaa057, 2021
Inhibitors of L-type calcium channels show therapeutic potential for treating SARS-CoV-2 infections by preventing virus entry and spread
MR Straus, MK Bidon, T Tang, JA Jaimes, GR Whittaker, S Daniel
ACS Infectious Diseases, 2021
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
JK Millet, T Tang, L Nathan, JA Jaimes, HL Hsu, S Daniel, GR Whittaker
JoVE (Journal of Visualized Experiments), e59010, 2019
Spike protein cleavage-activation in the context of the SARS-CoV-2 P681R mutation: an analysis from its first appearance in lineage A. 23.1 identified in Uganda
B Lubinski, LE Frazier, MVT Phan, DL Bugembe, JL Cunningham, T Tang, ...
Microbiology Spectrum, e01514-22, 2022
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
ER Kastenhuber, M Mercadante, B Nilsson-Payant, JL Johnson, ...
Elife 11, 2022
Las enfermedades infecciosas y su importancia en el sector avícola
JA Jaimes Olaya, AP Gómez Ramírez, DCM Álvarez Espejo, ...
Revista de Medicina Veterinaria, 49-61, 2010
Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and …
JA Jaimes, NM André, JK Millet, GR Whittaker
arXiv preprint arXiv:2002.06196, 2020
SARS-CoV-2 Clinical Outcome in Domestic and Wild Cats: A Systematic Review
S Giraldo-Ramirez, S Rendon-Marin, JA Jaimes, M Martinez-Gutierrez, ...
Animals 11 (7), 2056, 2021
SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex
V Vásquez, MC Navas, JA Jaimes, J Orozco
Analytica chimica acta 1205, 339718, 2022
Intrinsic furin-mediated cleavability of the spike S1/S2 site from SARS-CoV-2 variant B. 1.1. 529 (Omicron)
B Lubinski, JA Jaimes, GR Whittaker
BioRxiv, 2022.04. 20.488969, 2022
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
JA Jaimes, JK Millet, ME Goldstein, GR Whittaker, MR Straus
JoVE (Journal of Visualized Experiments), e58892, 2019
SARS CoV-2 Spike protein in silico interaction with ACE2 receptors from wild and domestic species
S Rendon-Marin, M Martinez-Gutierrez, GR Whittaker, JA Jaimes, ...
Frontiers in Genetics 12 (27), 2021
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