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Javier A. Jaimes
Javier A. Jaimes
Senior Research Scientist - University of Massachusetts Medical School
Dirección de correo verificada de umassmed.edu - Página principal
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Coronavirus membrane fusion mechanism offers a potential target for antiviral development
T Tang, M Bidon, JA Jaimes, GR Whittaker, S Daniel
Antiviral research 178, 104792, 2020
8262020
Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop
JA Jaimes, NM André, JS Chappie, JK Millet, GR Whittaker
Journal of molecular biology 432 (10), 3309-3325, 2020
5052020
Proteolytic cleavage of the SARS-CoV-2 spike protein and the role of the novel S1/S2 site
JA Jaimes, JK Millet, GR Whittaker
IScience 23 (6), 101212, 2020
3122020
Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B. 1.1. 7 (Alpha) spike
B Lubinski, MHV Fernandes, L Frazier, T Tang, S Daniel, DG Diel, ...
iScience 25 (1), 103589, 2022
194*2022
A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses
JA Jaimes, JK Millet, AE Stout, NM André, GR Whittaker
Viruses 12 (1), 83, 2020
1742020
Proteolytic activation of SARS-CoV-2 spike at the S1/S2 boundary: potential role of proteases beyond furin
T Tang, JA Jaimes, MK Bidon, MR Straus, S Daniel, GR Whittaker
ACS Infectious Diseases 7 (2), 264-271, 2021
1442021
Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit?
AE Stout, NM André, JA Jaimes, JK Millet, GR Whittaker
Veterinary microbiology 247, 108777, 2020
1422020
Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function
JA Jaimes, GR Whittaker
Virology 517, 108-121, 2018
1172018
Molecular diversity of coronavirus host cell entry receptors
JK Millet, JA Jaimes, GR Whittaker
FEMS microbiology reviews 45 (3), fuaa057, 2021
1122021
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
JK Millet, T Tang, L Nathan, JA Jaimes, HL Hsu, S Daniel, GR Whittaker
JoVE (Journal of Visualized Experiments), e59010, 2019
842019
Inhibitors of L-type calcium channels show therapeutic potential for treating SARS-CoV-2 infections by preventing virus entry and spread
MR Straus, MK Bidon, T Tang, JA Jaimes, GR Whittaker, S Daniel
ACS Infectious Diseases, 2021
83*2021
Spike protein cleavage-activation in the context of the SARS-CoV-2 P681R mutation: an analysis from its first appearance in lineage A. 23.1 identified in Uganda
B Lubinski, LE Frazier, MVT Phan, DL Bugembe, JL Cunningham, T Tang, ...
Microbiology Spectrum, e01514-22, 2022
71*2022
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
ER Kastenhuber, M Mercadante, B Nilsson-Payant, JL Johnson, ...
Elife 11, 2022
542022
Las enfermedades infecciosas y su importancia en el sector avícola
JA Jaimes Olaya, AP Gómez Ramírez, DCM Álvarez Espejo, ...
Revista de Medicina Veterinaria, 49-61, 2010
542010
Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and …
JA Jaimes, NM André, JK Millet, GR Whittaker
arXiv preprint arXiv:2002.06196, 2020
452020
SARS-CoV-2 Clinical Outcome in Domestic and Wild Cats: A Systematic Review
S Giraldo-Ramirez, S Rendon-Marin, JA Jaimes, M Martinez-Gutierrez, ...
Animals 11 (7), 2056, 2021
392021
SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex
V Vásquez, MC Navas, JA Jaimes, J Orozco
Analytica chimica acta 1205, 339718, 2022
322022
Intrinsic furin-mediated cleavability of the spike S1/S2 site from SARS-CoV-2 variant B. 1.1. 529 (Omicron)
B Lubinski, JA Jaimes, GR Whittaker
BioRxiv, 2022.04. 20.488969, 2022
282022
SARS CoV-2 Spike protein in silico interaction with ACE2 receptors from wild and domestic species
S Rendon-Marin, M Martinez-Gutierrez, GR Whittaker, JA Jaimes, ...
Frontiers in Genetics 12 (27), 2021
262021
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
JA Jaimes, JK Millet, ME Goldstein, GR Whittaker, MR Straus
JoVE (Journal of Visualized Experiments), e58892, 2019
262019
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