Al Sabirsh
Al Sabirsh
Principal Scientist, AstraZeneca
Verified email at
Cited by
Cited by
Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes
Å Segerstolpe, A Palasantza, P Eliasson, EM Andersson, AC Andréasson, ...
Cell metabolism 24 (4), 593-607, 2016
Role of B cell–activating factor in chronic obstructive pulmonary disease
LJM Seys, FM Verhamme, A Schinwald, H Hammad, DM Cunoosamy, ...
American journal of respiratory and critical care medicine 192 (6), 706-718, 2015
Human iPS-derived astroglia from a stable neural precursor state show improved functionality compared with conventional astrocytic models
A Lundin, L Delsing, M Clausen, P Ricchiuto, J Sanchez, A Sabirsh, ...
Stem cell reports 10 (3), 1030-1045, 2018
Long-term chronic toxicity testing using human pluripotent stem cell–derived hepatocytes
G Holmgren, AK Sjögren, I Barragan, A Sabirsh, P Sartipy, J Synnergren, ...
Drug Metabolism and Disposition 42 (9), 1401-1406, 2014
Leukotriene B4 triggers release of the cathelicidin LL‐37 from human neutrophils: novel lipid‐peptide interactions in innate immune responses
M Wan, A Sabirsh, A Wetterholm, B Agerberth, JZ Haeggstrom
The FASEB Journal 21 (11), 2897-2905, 2007
The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells
C Owman, A Garzino-Demo, F Cocchi, M Popovic, A Sabirsh, RC Gallo
Proceedings of the National Academy of Sciences 95 (16), 9530-9534, 1998
Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale
P Paramasivam, C Franke, M Stöter, A Höijer, S Bartesaghi, A Sabirsh, ...
Journal of Cell Biology 221 (2), e202110137, 2021
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms
T Borgegard, A Juréus, F Olsson, S Rosqvist, A Sabirsh, D Rotticci, ...
Journal of Biological Chemistry 287 (15), 11810-11819, 2012
A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery
MJ Munson, G O’Driscoll, AM Silva, E Lázaro-Ibáñez, A Gallud, JT Wilson, ...
Communications biology 4 (1), 211, 2021
Pro- and anti-inflammatory substances modulate expression of the leukotriene B4 receptor, BLT1, in human monocytes
A Pettersson, A Sabirsh, J Bristulf, K Kidd-Ljunggren, B Ljungberg, ...
Journal of leukocyte biology 77 (6), 1018-1025, 2005
Leukotriene B4is the functional ligand binding to and activating the cloned chemoattractant receptor, CMKRL1
C Owman, A Sabirsh, Å Boketoft, B Olde
Biochemical and biophysical research communications 240 (1), 162-166, 1997
Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants
AK Blakney, P Deletic, PF McKay, CR Bouton, M Ashford, RJ Shattock, ...
Journal of controlled release 330, 1250-1261, 2021
Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells
M Ding, H Andersson, S Martinsson, A Sabirsh, A Jonebring, QD Wang, ...
Scientific reports 10 (1), 13575, 2020
Residues from Transmembrane Helices 3 and 5 Participate in Leukotriene B4 Binding to BLT1
A Sabirsh, RP Bywater, J Bristulf, C Owman, JZ Haeggström
Biochemistry 45 (18), 5733-5744, 2006
Extracting quantitative biological information from bright-field cell images using deep learning
S Helgadottir, B Midtvedt, J Pineda, A Sabirsh, C B Adiels, S Romeo, ...
Biophysics Reviews 2 (3), 2021
First-generation monoclonal antibodies identifying the human leukotriene B4 receptor-1
A Pettersson, Å Boketoft, A Sabirsh, NE Nilsson, K Kotarsky, B Olde, ...
Biochemical and Biophysical Research Communications 279 (2), 520-525, 2000
Interaction kinetics of individual mRNA-containing lipid nanoparticles with an endosomal membrane mimic: dependence on pH, protein corona formation, and lipoprotein depletion
N Aliakbarinodehi, A Gallud, M Mapar, E Wesén, S Heydari, Y Jing, ...
ACS nano 16 (12), 20163-20173, 2022
Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease
M Herrera, M Söderberg, A Sabirsh, B Valastro, J Mölne, B Santamaria, ...
American Journal of Physiology-Renal Physiology 312 (4), F748-F759, 2017
A novel graphene quantum dot‐based mRNA delivery platform
Y Liu, C Zhao, A Sabirsh, L Ye, X Wu, H Lu, J Liu
ChemistryOpen 10 (7), 666-671, 2021
Deep-learning models for lipid nanoparticle-based drug delivery
PJ Harrison, H Wieslander, A Sabirsh, J Karlsson, V Malmsjö, A Hellander, ...
Nanomedicine 16 (13), 1097-1110, 2021
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