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Sarah A Head
Sarah A Head
Johns Hopkins School of Medicine
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Year
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein
JRPM Strating, L van der Linden, L Albulescu, J Bigay, M Arita, L Delang, ...
Cell reports 10 (4), 600-615, 2015
2402015
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
SA Head, W Shi, L Zhao, K Gorshkov, K Pasunooti, Y Chen, Z Deng, R Li, ...
Proceedings of the National Academy of Sciences 112 (52), E7276-E7285, 2015
1182015
Mechanistic insights into the activation of oncogenic forms of EGF receptor
Z Wang, PA Longo, MK Tarrant, K Kim, S Head, DJ Leahy, PA Cole
Nature structural & molecular biology 18 (12), 1388-1393, 2011
1012011
Itraconazole side chain analogues: structure–activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 …
W Shi, BA Nacev, BT Aftab, S Head, CM Rudin, JO Liu
Journal of medicinal chemistry 54 (20), 7363-7374, 2011
762011
Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
SA Head, WQ Shi, EJ Yang, BA Nacev, SY Hong, KK Pasunooti, R Li, ...
ACS Chemical Biology, 2016
742016
Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation
QL He, I Minn, Q Wang, P Xu, SA Head, E Datan, B Yu, MG Pomper, ...
Angewandte Chemie 128 (39), 12214-12218, 2016
712016
Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism
JS Shim, RJ Li, J Lv, SA Head, EJ Yang, JO Liu
Cancer letters 362 (1), 106-115, 2015
282015
Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole
JS Shim, RJ Li, NN Bumpus, SA Head, KK Pasunooti, EJ Yang, J Lv, ...
Clinical Cancer Research 22 (11), 2709-2720, 2016
152016
Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety
H Qiu, S Qian, SA Head, JO Liu, Z Jin
Bioorganic & Medicinal Chemistry Letters 26 (19), 4702-4704, 2016
92016
Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the …
S Qian, AK Shah, SA Head, JO Liu, Z Jin
Bioorganic & Medicinal Chemistry Letters 26 (15), 3411-3413, 2016
92016
Insights into the structure–activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring
AK Shah, S Qian, D Zhang, SA Head, JO Liu, Z Jin
Bioorganic & medicinal chemistry letters 26 (12), 2890-2892, 2016
82016
Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
SA Head, JO Liu
JoVE (Journal of Visualized Experiments), e54529-e54529, 2016
72016
Abstract C147: Itraconazole side-chain analogs reveal a distinct structure-activity relationship for inhibition of hedgehog pathway signaling.
BT Aftab, W Shi, BA Nacev, S Head, JO Liu, CM Rudin
Molecular Cancer Therapeutics 10 (11 Supplement), C147-C147, 2011
2011
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