James R. Fuchs
James R. Fuchs
Medicinal Chemistry & Pharmacognosy, Pharmacy, The Ohio State University
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Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner
TA Mace, Z Ameen, A Collins, S Wojcik, M Mair, GS Young, JR Fuchs, ...
Cancer research 73 (10), 3007-3018, 2013
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
L Lin, B Hutzen, M Zuo, S Ball, S Deangelis, E Foust, B Pandit, MA Ihnat, ...
Cancer research 70 (6), 2445-2454, 2010
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
KA Jurado, H Wang, A Slaughter, L Feng, JJ Kessl, Y Koh, W Wang, ...
Proceedings of the National Academy of Sciences 110 (21), 8690-8695, 2013
Reactions of SmI2 with Alkyl Halides and Ketones:  Inner-Sphere vs Outer-Sphere Electron Transfer in Reactions of Sm(II) Reductants
RS Miller, JM Sealy, M Shabangi, ML Kuhlman, JR Fuchs, RA Flowers
Journal of the American Chemical Society 122 (32), 7718-7722, 2000
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors
JJ Kessl, N Jena, Y Koh, H Taskent-Sezgin, A Slaughter, L Feng, ...
Journal of Biological Chemistry 287 (20), 16801-16811, 2012
Total synthesis of ()-perophoramidine
JR Fuchs, RL Funk
Journal of the American Chemical Society 126 (16), 5068-5069, 2004
Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030
L Lin, Y Liu, H Li, PK Li, J Fuchs, H Shibata, Y Iwabuchi, J Lin
British journal of cancer 105 (2), 212-220, 2011
Structure–activity relationship studies of curcumin analogues
JR Fuchs, B Pandit, D Bhasin, JP Etter, N Regan, D Abdelhamid, C Li, ...
Bioorganic & medicinal chemistry letters 19 (7), 2065-2069, 2009
Modulation of DNA methylation by a sesquiterpene lactone parthenolide
Z Liu, S Liu, Z Xie, RE Pavlovicz, J Wu, P Chen, J Aimiuwu, J Pang, ...
Journal of Pharmacology and Experimental Therapeutics 329 (2), 505-514, 2009
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
L Lin, S Deangelis, E Foust, J Fuchs, C Li, PK Li, EB Schwartz, ...
Molecular cancer 9, 1-10, 2010
STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cells
L Lin, J Fuchs, C Li, V Olson, T Bekaii-Saab, J Lin
Biochemical and biophysical research communications 416 (3-4), 246-251, 2011
HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis
JJ Kessl, SB Kutluay, D Townsend, S Rebensburg, A Slaughter, RC Larue, ...
Cell 166 (5), 1257-1268. e12, 2016
Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species
L Pan, JL Woodard, DM Lucas, JR Fuchs, AD Kinghorn
Natural product reports 31 (7), 924-939, 2014
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
MA Bill, JR Fuchs, C Li, J Yui, C Bakan, DM Benson, EB Schwartz, ...
Molecular cancer 9, 1-12, 2010
Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of ()-flustramines A and C
JR Fuchs, RL Funk
Organic Letters 7 (4), 677-680, 2005
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
SM Bester, G Wei, H Zhao, D Adu-Ampratwum, N Iqbal, VV Courouble, ...
Science 370 (6514), 360-364, 2020
A new class of multimerization selective inhibitors of HIV-1 integrase
A Sharma, A Slaughter, N Jena, L Feng, JJ Kessl, HJ Fadel, N Malani, ...
PLoS pathogens 10 (5), e1004171, 2014
The effect of cosolvent on the reducing power of SmI2 in tetrahydrofuran
M Shabangi, JM Sealy, JR Fuchs, RA Flowers II
Tetrahedron letters 39 (25), 4429-4432, 1998
Total synthesis of ()-Lennoxamine and ()-Aphanorphine by intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins
JR Fuchs, RL Funk
Organic Letters 3 (24), 3923-3925, 2001
Intramolecular Diels− Alder/1, 3-dipolar cycloaddition cascade of 1, 3, 4-oxadiazoles
GI Elliott, JR Fuchs, BSJ Blagg, H Ishikawa, H Tao, ZQ Yuan, DL Boger
Journal of the American Chemical Society 128 (32), 10589-10595, 2006
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