Richard LeDuc
Richard LeDuc
Bioinformatics Platform Director, Children's Hospital Research Institute of Manitoba
Verified email at
Cited by
Cited by
De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis
BJ Haas, A Papanicolaou, M Yassour, M Grabherr, PD Blood, J Bowden, ...
Nature Protocols 8 (8), 1494-1512, 2013
Mapping intact protein isoforms in discovery mode using top-down proteomics
JC Tran, L Zamdborg, DR Ahlf, JE Lee, AD Catherman, KR Durbin, ...
Nature 480 (7376), 254-258, 2011
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry
L Zamdborg, RD LeDuc, KJ Glowacz, YB Kim, V Viswanathan, ...
Nucleic acids research 35 (suppl 2), W701-W706, 2007
ProSight Lite: Graphical software to analyze top‐down mass spectrometry data
RT Fellers, JB Greer, BP Early, X Yu, RD LeDuc, NL Kelleher, PM Thomas
Proteomics 15 (7), 1235-1238, 2015
ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry
RD LeDuc, GK Taylor, YB Kim, TE Januszyk, LH Bynum, JV Sola, ...
Nucleic acids research 32 (suppl 2), W340-W345, 2004
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry
JJ Pesavento, CR Bullock, RD LeDuc, CA Mizzen, NL Kelleher
Journal of Biological Chemistry 283 (22), 14927-14937, 2008
Identification and Quantification of Proteoforms by Mass Spectrometry
LV Schaffer, RJ Millikin, RM Miller, LC Anderson, RT Fellers, Y Ge, ...
Proteomics 19 (10), 1800361, 2019
Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.
NC Wildburger, TJ Esparza, RD LeDuc, RT Fellers, PM Thomas, ...
Scientific reports 7 (1), 9520, 2017
The first pilot project of the consortium for top‐down proteomics: A status report
X Dang, J Scotcher, S Wu, RK Chu, N Tolić, I Ntai, PM Thomas, RT Fellers, ...
Proteomics 14 (10), 1130-1140, 2014
Applying label-free quantitation to top down proteomics
I Ntai, K Kim, RT Fellers, OS Skinner, AD Smith IV, BP Early, JP Savaryn, ...
Analytical chemistry 86 (10), 4961-4968, 2014
Identification and characterization of human proteoforms by top-down LC-21 tesla FT-ICR mass spectrometry
LC Anderson, CJ DeHart, NK Kaiser, RT Fellers, DF Smith, JB Greer, ...
Journal of proteome research 16 (2), 1087-1096, 2017
High-throughput analysis of intact human proteins using UVPD and HCD on an Orbitrap mass spectrometer
TP Cleland, CJ DeHart, RT Fellers, AJ VanNispen, JB Greer, RD LeDuc, ...
Journal of Proteome Research 16 (5), 2072-2079, 2017
New and automated MS n approaches for top-down identification of modified proteins
V Zabrouskov, MW Senko, Y Du, RD Leduc, NL Kelleher
Journal of the American Society for Mass Spectrometry 16 (12), 2027-2038, 2005
Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk
I Ntai, L Fornelli, CJ DeHart, JE Hutton, PF Doubleday, RD LeDuc, ...
Proceedings of the National Academy of Sciences 115 (16), 4140-4145, 2018
Integrated bottom-up and top-down proteomics of patient-derived breast tumor xenografts
I Ntai, RD LeDuc, RT Fellers, P Erdmann-Gilmore, SR Davies, J Rumsey, ...
Molecular & Cellular Proteomics 15 (1), 45-56, 2016
Advancing top-down analysis of the human proteome using a benchtop quadrupole-Orbitrap mass spectrometer
L Fornelli, KR Durbin, RT Fellers, BP Early, JB Greer, RD LeDuc, ...
Journal of Proteome Research 16 (2), 609-618, 2016
The C-score: a Bayesian framework to sharply improve proteoform scoring in high-throughput top down proteomics
RD LeDuc, RT Fellers, BP Early, JB Greer, PM Thomas, NL Kelleher
Journal of proteome research 13 (7), 3231-3240, 2014
Trinity RNA-Seq assembler performance optimization
R Henschel, M Lieber, LS Wu, PM Nista, BJ Haas, RD LeDuc
Proceedings of the 1st Conference of the Extreme Science and Engineering …, 2012
An informatic framework for decoding protein complexes by top-down mass spectrometry
OS Skinner, PC Havugimana, NA Haverland, L Fornelli, BP Early, ...
Nature methods 13 (3), 237-240, 2016
A comprehensive pipeline for translational top-down proteomics from a single blood draw
TK Toby, L Fornelli, S Kristina, CJ DeHart, RT Fellers, RD LeDuc, ...
Nature Protocols, 2016
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