| CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1 XC Junjie Xu, Lin Ji, Yuelong Liang, Zhe Wan, Wei Zheng, Xiaomin Song ... Signal Transduction and Targeted Therapy, 2020 | 246 | 2020 |
| N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling J Xu, Z Wan, M Tang, Z Lin, S Jiang, L Ji, K Gorshkov, Q Mao, S Xia, ... Molecular cancer 19, 1-16, 2020 | 189 | 2020 |
| RNA-dependent RNA polymerase as a target for COVID-19 drug discovery W Zhu, CZ Chen, K Gorshkov, M Xu, DC Lo, W Zheng SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (10), 1141-1151, 2020 | 166 | 2020 |
| Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry S Yang, M Xu, EM Lee, K Gorshkov, SA Shiryaev, S He, W Sun, ... Cell discovery 4 (1), 31, 2018 | 143 | 2018 |
| Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells SA Head, W Shi, L Zhao, K Gorshkov, K Pasunooti, Y Chen, Z Deng, R Li, ... Proceedings of the National Academy of Sciences 112 (52), E7276-E7285, 2015 | 117 | 2015 |
| The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules K Gorshkov, CZ Chen, R Bostwick, L Rasmussen ACS Infectious Diseases, 2020 | 113* | 2020 |
| Drug discovery strategies for SARS-CoV-2 ZA Shyr, K Gorshkov, CZ Chen, W Zheng Journal of Pharmacology and Experimental Therapeutics 375 (1), 127-138, 2020 | 102 | 2020 |
| Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles CZ Chen, M Xu, M Pradhan, K Gorshkov, JD Petersen, MR Straus, W Zhu, ... ACS Pharmacology & Translational Science 3 (6), 1165-1175, 2020 | 101 | 2020 |
| Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators T Miyamoto, E Rho, V Sample, H Akano, M Magari, T Ueno, K Gorshkov, ... Cell reports 11 (4), 657-670, 2015 | 101 | 2015 |
| Quantum dot-conjugated Sars-cov-2 spike pseudo-virions enable tracking of angiotensin converting enzyme 2 binding and endocytosis K Gorshkov, K Susumu, J Chen, M Xu, M Pradhan, W Zhu, X Hu, ... ACS Nano 14 (9), 12234-12247, 2020 | 96 | 2020 |
| Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin S Mehta, NN Aye-Han, A Ganesan, L Oldach, K Gorshkov, J Zhang Elife 3, e03765, 2014 | 78 | 2014 |
| Induced pluripotent stem cells for neural drug discovery A Farkhondeh, R Li, K Gorshkov, KG Chen, M Might, S Rodems, DC Lo, ... Drug discovery today 24 (4), 992-999, 2019 | 77 | 2019 |
| An OpenData portal to share COVID-19 drug repurposing data in real time KR Brimacombe, T Zhao, RT Eastman, X Hu, K Wang, M Backus, ... BioRxiv, 2020 | 74 | 2020 |
| Zika Virus: Origins, Pathological Action, and Treatment Strategies. K Gorshkov, S Shiryaev, S Fertel, YW Lin, CT Huang, A Pinto, C Farhy, ... Frontiers in Microbiology 9, 3252, 2018 | 72 | 2018 |
| Astrocytes as targets for drug discovery K Gorshkov, F Aguisanda, N Thorne, W Zheng Drug discovery today 23 (3), 673-680, 2018 | 64 | 2018 |
| Assay guidance manual [Internet] S Markossian, A Grossman, K Brimacombe, M Arkin, D Auld, C Austin, ... Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004 | 63 | 2004 |
| AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons K Gorshkov, S Mehta, S Ramamurthy, GV Ronnett, FQ Zhou, J Zhang Nature chemical biology 13 (4), 425-431, 2017 | 46 | 2017 |
| Polarized activities of AMPK and BRSK in primary hippocampal neurons V Sample, S Ramamurthy, K Gorshkov, GV Ronnett, J Zhang Molecular biology of the cell 26 (10), 1935-1946, 2015 | 39 | 2015 |
| Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease M Vu, R Li, A Baskfield, B Lu, A Farkhondeh, K Gorshkov, O Motabar, ... Orphanet Journal of Rare Diseases 13 (152), 2018 | 38 | 2018 |
| Zika virus-induced neuronal apoptosis via increased mitochondrial fragmentation S Yang, K Gorshkov, EM Lee, M Xu, YS Cheng, N Sun, F Soheilian, ... Frontiers in microbiology 11, 598203, 2020 | 35 | 2020 |
Ruojing LiUS Food and Drug AdministrationVerified email at fda.hhs.gov
