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Sophie Stukas
Sophie Stukas
PhD,University of British Columbia
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Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome
LYC Chen, RL Hoiland, S Stukas, CL Wellington, MS Sekhon
European Respiratory Journal 56 (4), 2020
2402020
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor …
JJ Donkin, S Stukas, V Hirsch-Reinshagen, D Namjoshi, A Wilkinson, ...
Journal of Biological Chemistry 285 (44), 34144-34154, 2010
2402010
The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19
RL Hoiland, NA Fergusson, AR Mitra, DEG Griesdale, DV Devine, ...
Blood advances 4 (20), 4981-4989, 2020
1852020
Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels
J Robert, EB Button, B Yuen, M Gilmour, K Kang, A Bahrabadi, S Stukas, ...
Elife 6, e29595, 2017
1172017
High-density lipoproteins and cerebrovascular integrity in Alzheimer’s disease
S Stukas, J Robert, CL Wellington
Cell metabolism 19 (4), 574-591, 2014
1002014
Intravenously injected human apolipoprotein A‐I rapidly enters the central nervous system via the choroid plexus
S Stukas, J Robert, M Lee, I Kulic, M Carr, K Tourigny, J Fan, D Namjoshi, ...
Journal of the American Heart Association 3 (6), e001156, 2014
952014
Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice
J Robert, S Stukas, E Button, WH Cheng, M Lee, J Fan, A Wilkinson, ...
Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (5 …, 2016
872016
Defining the biomechanical and biological threshold of murine mild traumatic brain injury using CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration)
DR Namjoshi, WH Cheng, A Bashir, A Wilkinson, S Stukas, KM Martens, ...
Experimental neurology 292, 80-91, 2017
832017
ABCA1 influences neuroinflammation and neuronal death
JM Karasinska, W de Haan, S Franciosi, P Ruddle, J Fan, JK Kruit, ...
Neurobiology of disease 54, 445-455, 2013
782013
LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins
V Hirsch-Reinshagen, J Donkin, S Stukas, J Chan, A Wilkinson, J Fan, ...
Journal of lipid research 50 (5), 885-893, 2009
772009
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo
BL Burgess, PF Parkinson, MM Racke, V Hirsch-Reinshagen, J Fan, ...
Journal of lipid research 49 (6), 1254-1267, 2008
702008
CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice
WH Cheng, KM Martens, A Bashir, H Cheung, S Stukas, E Gibbs, ...
Alzheimer's research & therapy 11, 1-21, 2019
652019
The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E
DR Namjoshi, G Martin, J Donkin, A Wilkinson, S Stukas, J Fan, M Carr, ...
PloS one 8 (1), e53529, 2013
652013
Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
LYC Chen, CM Biggs, S Jamal, S Stukas, CL Wellington, MS Sekhon
Cell Reports Medicine 2 (5), 2021
542021
Assessing the importance of interleukin-6 in COVID-19
LYC Chen, RL Hoiland, S Stukas, CL Wellington, MS Sekhon
The Lancet Respiratory Medicine 9 (2), e13, 2021
542021
High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture
J Robert, EB Button, S Stukas, GK Boyce, E Gibbs, CM Cowan, M Gilmour, ...
Molecular neurodegeneration 12, 1-19, 2017
522017
Quantification of neurological blood-based biomarkers in critically ill patients with coronavirus disease 2019
J Cooper, S Stukas, RL Hoiland, NA Fergusson, S Thiara, D Foster, ...
Critical care explorations 2 (10), e0238, 2020
472020
Brain hypoxia is associated with neuroglial injury in humans post–cardiac arrest
RL Hoiland, PN Ainslie, CL Wellington, J Cooper, S Stukas, S Thiara, ...
Circulation Research 129 (5), 583-597, 2021
452021
Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice
WH Cheng, S Stukas, KM Martens, DR Namjoshi, EB Button, A Wilkinson, ...
Experimental neurology 301, 26-38, 2018
452018
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP …
EB Button, GK Boyce, A Wilkinson, S Stukas, A Hayat, J Fan, ...
Alzheimer's research & therapy 11, 1-18, 2019
432019
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Articles 1–20