| Harnessing the anti-cancer natural product nimbolide for targeted protein degradation JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ... Nature chemical biology 15 (7), 747-755, 2019 | 312 | 2019 |
| Deubiquitinase-targeting chimeras for targeted protein stabilization NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ... Nature chemical biology 18 (4), 412-421, 2022 | 155 | 2022 |
| Discovery of a covalent FEM1B recruiter for targeted protein degradation applications NJ Henning, AG Manford, JN Spradlin, SM Brittain, E Zhang, JM McKenna, ... Journal of the American Chemical Society 144 (2), 701-708, 2022 | 109 | 2022 |
| Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products EA Grossman, CC Ward, JN Spradlin, LA Bateman, TR Huffman, ... Cell chemical biology 24 (11), 1368-1376. e4, 2017 | 108 | 2017 |
| Bardoxolone conjugation enables targeted protein degradation of BRD4 B Tong, M Luo, Y Xie, JN Spradlin, JA Tallarico, JM McKenna, M Schirle, ... Scientific reports 10 (1), 15543, 2020 | 99 | 2020 |
| Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function M Luo, JN Spradlin, L Boike, B Tong, SM Brittain, JM McKenna, ... Cell chemical biology 28 (4), 559-566. e15, 2021 | 95 | 2021 |
| Reimagining druggability using chemoproteomic platforms JN Spradlin, E Zhang, DK Nomura Accounts of Chemical Research 54 (7), 1801-1813, 2021 | 79 | 2021 |
| A nimbolide-based kinase degrader preferentially degrades oncogenic BCR-ABL B Tong, JN Spradlin, LFT Novaes, E Zhang, X Hu, M Moeller, SM Brittain, ... ACS chemical biology 15 (7), 1788-1794, 2020 | 79 | 2020 |
| Unbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in small cell lung cancer stem cells GL Coles, S Cristea, JT Webber, RS Levin, SM Moss, A He, J Sangodkar, ... Cancer Cell 38 (1), 129-143. e7, 2020 | 67 | 2020 |
| Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2 SB Biering, E Van Dis, E Wehri, LH Yamashiro, X Nguyenla, ... ACS infectious diseases 7 (8), 2337-2351, 2021 | 25 | 2021 |
| Insights into an efficient light-driven hybrid P450 BM3 enzyme from crystallographic, spectroscopic and biochemical studies J Spradlin, D Lee, S Mahadevan, M Mahomed, L Tang, Q Lam, A Colbert, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864 (12), 1732-1738, 2016 | 22 | 2016 |
| Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design ACS Page, SO Scholz, KN Keenan, JN Spradlin, BP Belcher, SM Brittain, ... Chemical science 13 (13), 3851-3856, 2022 | 20 | 2022 |
| Toward abiotic sugar synthesis from CO2 electrolysis S Cestellos-Blanco, S Louisia, MB Ross, Y Li, NE Soland, TC Detomasi, ... Joule 6 (10), 2304-2323, 2022 | 19 | 2022 |
| De novo Design of SARS-CoV-2 Main Protease Inhibitors C Fischer, NA Vepřek, Z Peitsinis, KP Rühmann, C Yang, JN Spradlin, ... Synlett 33 (05), 458-463, 2022 | 10 | 2022 |
| Discovery of Potent Pyrazoline‐Based Covalent SARS‐CoV‐2 Main Protease Inhibitors P Moon, CM Zammit, Q Shao, D Dovala, L Boike, NJ Henning, M Knapp, ... ChemBioChem 24 (11), e202300116, 2023 | 9 | 2023 |
| Targeted protein degradation via a covalent reversible degrader based on bardoxolone B Tong, M Luo, Y Xie, J Spradlin, JA Tallarico, JM McKenna, M Schirle, ... | 9 | 2020 |
| Chemoproteomics-enabled ligand screening yields covalent RNF114-based degraders that mimic natural product function M Luo, JN Spradlin, SM Brittain, JM McKenna, JA Tallarico, M Schirle, ... bioRxiv, 2020.07. 12.198150, 2020 | 2 | 2020 |
| Correction to “Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications” NJ Henning, AG Manford, JN Spradlin, SM Brittain, E Zhang, JM McKenna, ... Journal of the American Chemical Society 145 (38), 21142-21142, 2023 | | 2023 |
| Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors (preprint) P Moon, L Boike, D Dovala, N Henning, M Knapp, J Spradlin, C Ward, ... | | 2022 |
| Photo-Brook rearrangement of acyl silanes as a new tool for photoaffinity probes design J McKenna, M Schirle, J Tallarico, S Brittain, S Scholz, K Near, A Page, ... Chem Sci, 2022 | | 2022 |
