Yogavel Manickam
Yogavel Manickam
Research Scientist (P), ICGEB, New Delhi
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A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
L Braun, MP Brenier-Pinchart, M Yogavel, A Curt-Varesano, ...
Journal of Experimental Medicine 210 (10), 2071-2086, 2013
Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis
V Jain, M Yogavel, Y Oshima, H Kikuchi, B Touquet, MA Hakimi, ...
Structure 23 (5), 819-829, 2015
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B Baragaņa, B Forte, R Choi, S Nakazawa Hewitt, JA Bueren-Calabuig, ...
Proceedings of the National Academy of Sciences 116 (14), 7015-7020, 2019
Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion
A Bansal, S Singh, KR More, D Hans, K Nangalia, M Yogavel, A Sharma, ...
Journal of Biological Chemistry 288 (3), 1590-1602, 2013
Structural analysis of ABC-family periplasmic zinc binding protein provides new insights into mechanism of ligand uptake and release
BR Chandra, M Yogavel, A Sharma
Journal of molecular biology 367 (4), 970-982, 2007
Targeting prolyl-tRNA synthetase to accelerate drug discovery against malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, and coccidiosis
V Jain, M Yogavel, H Kikuchi, Y Oshima, N Hariguchi, M Matsumoto, ...
Structure 25 (10), 1495-1505. e6, 2017
Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses
TK Bhatt, S Khan, VP Dwivedi, MM Banday, A Sharma, A Chandele, ...
Nature communications 2 (1), 530, 2011
Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin
S Khan, A Sharma, H Belrhali, M Yogavel, A Sharma
Journal of structural and functional genomics 15, 63-71, 2014
Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum
Y Manickam, R Chaturvedi, P Babbar, N Malhotra, V Jain, A Sharma
Drug discovery today 23 (6), 1233-1240, 2018
Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases
T Hussain, M Yogavel, A Sharma
Antimicrobial agents and chemotherapy 59 (4), 1856-1867, 2015
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase
V Jain, H Kikuchi, Y Oshima, A Sharma, M Yogavel
Journal of structural and functional genomics 15, 181-190, 2014
Specific stereoisomeric conformations determine the drug potency of cladosporin scaffold against malarial parasite
P Das, P Babbar, N Malhotra, M Sharma, GR Jachak, RG Gonnade, ...
Journal of Medicinal Chemistry 61 (13), 5664-5678, 2018
Crystal structure of malaria parasite nucleosome assembly protein
J Gill, M Yogavel, A Kumar, H Belrhali, SK Jain, M Rug, M Brown, ...
Journal of Biological Chemistry 284 (15), 10076-10087, 2009
Crystal structure of soluble domain of malaria sporozoite protein UIS3 in complex with lipid
A Sharma, M Yogavel, RR Akhouri, J Gill, A Sharma
Journal of Biological Chemistry 283 (35), 24077-24088, 2008
Ligand-bound structures provide atomic snapshots for the catalytic mechanism of D-amino acid deacylase
TK Bhatt, M Yogavel, S Wydau, R Berwal, A Sharma
Journal of biological chemistry 285 (8), 5917-5930, 2010
Structure of a superoxide dismutase and implications for copper-ion chelation
M Yogavel, PC Mishra, J Gill, PK Bhardwaj, S Dutt, S Kumar, PS Ahuja, ...
Acta Crystallographica Section D: Biological Crystallography 64 (8), 892-901, 2008
Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum
J Gill, A Kumar, M Yogavel, H Belrhali, SK Jain, M Rug, M Brown, ...
Malaria journal 9, 1-15, 2010
Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2
K Sekar, SV Mala, M Yogavel, D Velmurugan, MJ Poi, BS Vishwanath, ...
Journal of molecular biology 333 (2), 367-376, 2003
SAD phasing of a structure based on cocrystallized iodides using an in-house Cu Kα X-ray source: effects of data redundancy and completeness on structure solution
M Yogavel, J Gill, PC Mishra, A Sharma
Acta Crystallographica Section D: Biological Crystallography 63 (8), 931-934, 2007
Protein translation enzyme lysyl-tRNA synthetase presents a new target for drug development against causative agents of loiasis and schistosomiasis
A Sharma, M Sharma, M Yogavel, A Sharma
PLoS neglected tropical diseases 10 (11), e0005084, 2016
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