Proteome-wide covalent ligand discovery in native biological systems KM Backus, BE Correia, KM Lum, S Forli, BD Horning, GE González-Páez, ... Nature 534 (7608), 570-574, 2016 | 735 | 2016 |
An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers GR Villa, JJ Hulce, C Zanca, J Bi, S Ikegami, GL Cahill, Y Gu, KM Lum, ... Cancer cell 30 (5), 683-693, 2016 | 277 | 2016 |
An activity-guided map of electrophile-cysteine interactions in primary human T cells EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ... Cell 182 (4), 1009-1026. e29, 2020 | 219 | 2020 |
A global map of lipid-binding proteins and their ligandability in cells MJ Niphakis, KM Lum, AB Cognetta, BE Correia, TA Ichu, J Olucha, ... Cell 161 (7), 1668-1680, 2015 | 214 | 2015 |
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates JW Chang, MJ Niphakis, KM Lum, AB Cognetta, C Wang, ML Matthews, ... Chemistry & biology 19 (5), 579-588, 2012 | 213 | 2012 |
Chemical proteomic profiling of human methyltransferases BD Horning, RM Suciu, DA Ghadiri, OA Ulanovskaya, ML Matthews, ... Journal of the American Chemical Society 138 (40), 13335-13343, 2016 | 91 | 2016 |
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth JR Remsberg, RM Suciu, NA Zambetti, TW Hanigan, AJ Firestone, ... Nature chemical biology 17 (8), 856-864, 2021 | 52 | 2021 |
Single-cell profiling and SCOPE-Seq reveal lineage dynamics of adult ventricular-subventricular zone neurogenesis and NOTUM as a key regulator D Mizrak, NS Bayin, J Yuan, Z Liu, RM Suciu, MJ Niphakis, N Ngo, ... Cell reports 31 (12), 2020 | 48 | 2020 |
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors J Tan, AB Cognetta III, DB Diaz, KM Lum, S Adachi, S Kundu, BF Cravatt, ... Nature communications 8 (1), 1760, 2017 | 47 | 2017 |
Carbamate compounds and of making and using same JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ... US Patent 9,133,148, 2015 | 42 | 2015 |
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan AL Chen, KM Lum, P Lara-Gonzalez, D Ogasawara, AB Cognetta III, A To, ... Nature chemical biology 15 (5), 453-462, 2019 | 41 | 2019 |
Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors BW Zaro, LR Whitby, KM Lum, BF Cravatt Journal of the American Chemical Society 138 (49), 15841-15844, 2016 | 37 | 2016 |
Carbamate compounds and of making and using same JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ... US Patent 9,487,495, 2016 | 36 | 2016 |
AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice ME Ertunc, BP Kok, WH Parsons, JG Wang, D Tan, CJ Donaldson, ... Journal of Biological Chemistry 295 (18), 5891-5905, 2020 | 31 | 2020 |
Mapping protein targets of bioactive small molecules using lipid-based chemical proteomics KM Lum, Y Sato, BA Beyer, WC Plaisted, JL Anglin, LL Lairson, ... ACS chemical biology 12 (10), 2671-2681, 2017 | 29 | 2017 |
Stabilized Wittig olefination for bioconjugation KM Lum, VJ Xavier, MJH Ong, CW Johannes, KP Chan Chemical communications 49 (95), 11188-11190, 2013 | 25 | 2013 |
Carbamate compounds and methods of making and using same JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ... US Patent 9,957,242, 2018 | 14 | 2018 |
3-Oxo-β-sultam as a sulfonylating chemotype for inhibition of serine hydrolases and activity-based protein profiling LAR Carvalho, VT Almeida, JA Brito, KM Lum, TF Oliveira, RC Guedes, ... ACS Chemical Biology 15 (4), 878-883, 2020 | 10 | 2020 |
Carbamate compounds and methods of making and using same JS Cisar, CA Grice, TK Jones, MJ Niphakis, JW Chang, KM Lum, ... US Patent App. 15/925,517, 2018 | 10 | 2018 |
Chemoproteomik‐basierte Identifikation von 4‐Oxo‐β‐lactamen als Inhibitoren der Dipeptidylpeptidasen 8 und 9 LAR Carvalho, B Ross, L Fehr, O Bolgi, S Wöhrle, KM Lum, ... Angewandte Chemie 134 (47), e202210498, 2022 | 7 | 2022 |