Tracking cancer drugs in living cells by thermal profiling of the proteome MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ... Science 346 (6205), 1255784, 2014 | 1094 | 2014 |
The target landscape of clinical kinase drugs S Klaeger, S Heinzlmeir, M Wilhelm, H Polzer, B Vick, PA Koenig, ... Science 358 (6367), eaan4368, 2017 | 811 | 2017 |
A large peptidome dataset improves HLA class I epitope prediction across most of the human population S Sarkizova, S Klaeger, PM Le, LW Li, G Oliveira, H Keshishian, ... Nature biotechnology 38 (2), 199-209, 2020 | 431 | 2020 |
Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma G Oliveira, K Stromhaug, S Klaeger, T Kula, DT Frederick, PM Le, ... Nature 596 (7870), 119-125, 2021 | 369 | 2021 |
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells NR Mathew, F Baumgartner, L Braun, D O'Sullivan, S Thomas, ... Nature medicine 24 (3), 282-291, 2018 | 286 | 2018 |
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments H Hahne, F Pachl, B Ruprecht, SK Maier, S Klaeger, D Helm, G Médard, ... Nature methods 10 (10), 989-991, 2013 | 257 | 2013 |
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity GK Griffin, J Wu, A Iracheta-Vellve, JC Patti, J Hsu, T Davis, D Dele-Oni, ... Nature 595 (7866), 309-314, 2021 | 255 | 2021 |
Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer T Ouspenskaia, T Law, KR Clauser, S Klaeger, S Sarkizova, F Aguet, B Li, ... Nature biotechnology 40 (2), 209-217, 2022 | 227 | 2022 |
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics M Wilhelm, DP Zolg, M Graber, S Gessulat, T Schmidt, K Schnatbaum, ... Nature communications 12 (1), 3346, 2021 | 152 | 2021 |
Optimized chemical proteomics assay for kinase inhibitor profiling G Médard, F Pachl, B Ruprecht, S Klaeger, S Heinzlmeir, D Helm, H Qiao, ... Journal of proteome research 14 (3), 1574-1586, 2015 | 150 | 2015 |
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma G Oliveira, K Stromhaug, N Cieri, JB Iorgulescu, S Klaeger, JO Wolff, ... Nature 605 (7910), 532-538, 2022 | 121 | 2022 |
Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs S Weingarten-Gabbay, S Klaeger, S Sarkizova, LR Pearlman, DY Chen, ... Cell 184 (15), 3962-3980. e17, 2021 | 119 | 2021 |
Plant cytokinesis is orchestrated by the sequential action of the TRAPPII and exocyst tethering complexes K Rybak, A Steiner, L Synek, S Klaeger, I Kulich, E Facher, G Wanner, ... Developmental Cell 29 (5), 607-620, 2014 | 111 | 2014 |
Chemical proteomics reveals ferrochelatase as a common off-target of kinase inhibitors S Klaeger, B Gohlke, J Perrin, V Gupta, S Heinzlmeir, D Helm, H Qiao, ... ACS chemical biology 11 (5), 1245-1254, 2016 | 100 | 2016 |
Pharmacoproteomic characterisation of human colon and rectal cancer M Frejno, R Zenezini Chiozzi, M Wilhelm, H Koch, R Zheng, S Klaeger, ... Molecular systems biology 13 (11), 951, 2017 | 60 | 2017 |
Optimized Plk1 PBD inhibitors based on poloxin induce mitotic arrest and apoptosis in tumor cells A Scharow, M Raab, K Saxena, S Sreeramulu, D Kudlinzki, S Gande, ... ACS chemical biology 10 (11), 2570-2579, 2015 | 59 | 2015 |
Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs S Heinzlmeir, D Kudlinzki, S Sreeramulu, S Klaeger, SL Gande, V Linhard, ... ACS chemical biology 11 (12), 3400-3411, 2016 | 57 | 2016 |
Optimized liquid and gas phase fractionation increases HLA-peptidome coverage for primary cell and tissue samples S Klaeger, A Apffel, KR Clauser, S Sarkizova, G Oliveira, S Rachimi, ... Molecular & Cellular Proteomics 20, 2021 | 45 | 2021 |
Cell cycle‐regulated PLEIADE/At MAP 65‐3 links membrane and microtubule dynamics during plant cytokinesis A Steiner, K Rybak, M Altmann, HE McFarlane, S Klaeger, N Nguyen, ... The Plant Journal 88 (4), 531-541, 2016 | 40 | 2016 |
Interactions between transport protein particle (TRAPP) complexes and Rab GTP ases in Arabidopsis M Kalde, L Elliott, R Ravikumar, K Rybak, M Altmann, S Klaeger, C Wiese, ... The Plant Journal 100 (2), 279-297, 2019 | 37 | 2019 |