Kevin H. Gardner

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Lewis E KayUniversity of TorontoVerified email at pound.med.utoronto.ca
Michael RosenUT Southwestern Medical CenterVerified email at utsouthwestern.edu
Laura Mena MottaDirector, Methodist Health SystemVerified email at mhd.com
Carrie PartchProfessor of Biochemistry, UC Santa CruzVerified email at ucsc.edu
Wen-huang KoUniversity of Texas Southwestern medical center at dallasVerified email at utsouthwestern.edu
Uttam Krishnan TambarProfessor, UT Southwestern Medical CenterVerified email at utsouthwestern.edu
Jason KeyHarvard Medical SchoolVerified email at crystal.harvard.edu
Spencer GlantzHead of R&D, Detect IncVerified email at detect.com
Jared RutterDepartment of Biochemistry and HHMI, University of UtahVerified email at biochem.utah.edu
Igor Dikiy, PhDProtein Biochemistry, Regeneron PharmaceuticalsVerified email at regeneron.com
Brian ZoltowskiSouthern Methodist UniversityVerified email at smu.edu
Diana R TomchickUT Southwestern Medical CenterVerified email at utsouthwestern.edu
Doug E. FrantzMax and Minnie Tomerlin Voelcker Distinguished Professor of Chemistry, UTSAVerified email at utsa.edu
Lindsay ClarkPostdoc researcher, Harvard Medical SchoolVerified email at hms.harvard.edu
Daniel RosenbaumProfessor of Biophysics, UT SouthwesternVerified email at utsouthwestern.edu
Brian Y. ChowAssociate Professor of Bioengineering, University of PennsylvaniaVerified email at seas.upenn.edu
Orion D. WeinerProfessor, University of California, San FranciscoVerified email at ucsf.edu
Lynne ReganUniversity of EdinburghVerified email at ed.ac.uk
Jacinth NaidooUTSouthwestern Medical CenterVerified email at utsouthwestern.edu
John M. ChristieProfessor of Photobiology, University of GlasgowVerified email at glasgow.ac.uk

Kevin H. Gardner

Director, Structural Biology Initiative - CUNY Advanced Science Research Center; Professor – CCNY

Verified email at gc.cuny.edu - Homepage

Structural biology Allostery Protein/Ligand interactions Environmental Sensing


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Structural basis of a phototropin light switch SM Harper, LC Neil, KH Gardner Science 301 (5639), 1541-1544, 2003	868	2003
THE USE OF ²H, ¹³C, ¹⁵N MULTIDIMENSIONAL NMR GTO STUDY THE STRUCTURE AND DYNAMICS OF PROTEINS KH Gardner, LE Kay Annual review of biophysics and biomolecular structure 27 (1), 357-406, 1998	784	1998
A robust and cost-effective method for the production of Val, Leu, Ile (δ1) methyl-protonated 15N-, 13C-, 2H-labeled proteins NK Goto, KH Gardner, GA Mueller, RC Willis, LE Kay Journal of biomolecular NMR 13, 369-374, 1999	599	1999
Targeting renal cell carcinoma with a HIF-2 antagonist W Chen, H Hill, A Christie, MS Kim, E Holloman, A Pavia-Jimenez, ... Nature 539 (7627), 112-117, 2016	576	2016
White collar-1, a DNA binding transcription factor and a light sensor Q He, P Cheng, Y Yang, L Wang, KH Gardner, Y Liu Science 297 (5582), 840-843, 2002	492	2002
Evolutionary information for specifying a protein fold M Socolich, SW Lockless, WP Russ, H Lee, KH Gardner, R Ranganathan Nature 437 (7058), 512-518, 2005	491	2005
Selective methyl group protonation of perdeuterated proteins MK Rosen, KH Gardner, RC Willis, WE Parris, T Pawson, LE Kay Journal of molecular biology 263 (5), 627-636, 1996	359	1996
Disruption of the LOV− Jα helix interaction activates phototropin kinase activity SM Harper, JM Christie, KH Gardner Biochemistry 43 (51), 16184-16192, 2004	355	2004
An optogenetic gene expression system with rapid activation and deactivation kinetics LB Motta-Mena, A Reade, MJ Mallory, S Glantz, OD Weiner, KW Lynch, ... Nature chemical biology 10 (3), 196-202, 2014	346	2014
Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR KH Gardner, MK Rosen, LE Kay Biochemistry 36 (6), 1389-1401, 1997	324	1997
Production and incorporation of 15N, 13C, 2H (1H-δ1 methyl) isoleucine into proteins for multidimensional NMR studies KH Gardner, LE Kay Journal of the American Chemical Society 119 (32), 7599-7600, 1997	315	1997
Allosteric inhibition of hypoxia inducible factor-2 with small molecules TH Scheuermann, Q Li, HW Ma, J Key, L Zhang, R Chen, JA Garcia, ... Nature chemical biology 9 (4), 271-276, 2013	275	2013
Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor TH Scheuermann, DR Tomchick, M Machius, Y Guo, RK Bruick, ... Proceedings of the National Academy of Sciences 106 (2), 450-455, 2009	267	2009
Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor PJA Erbel, PB Card, O Karakuzu, RK Bruick, KH Gardner Proceedings of the National Academy of Sciences 100 (26), 15504-15509, 2003	256	2003
Solution NMR spectroscopy beyond 25 kDa LE Kay, KH Gardner Current opinion in structural biology 7 (5), 722-731, 1997	251	1997
Identification of small-molecule antagonists that inhibit an activator: coactivator interaction JL Best, CA Amezcua, B Mayr, L Flechner, CM Murawsky, B Emerson, ... Proceedings of the National Academy of Sciences 101 (51), 17622-17627, 2004	226	2004
Rationally improving LOV domain–based photoswitches D Strickland, X Yao, G Gawlak, MK Rosen, KH Gardner, TR Sosnick Nature methods 7 (8), 623-626, 2010	217	2010
PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses … P Cheng, Y Yang, KH Gardner, Y Liu Molecular and Cellular Biology 22 (2), 517-524, 2002	205	2002
Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transduction A Jung, T Domratcheva, M Tarutina, Q Wu, W Ko, RL Shoeman, ... Proceedings of the National Academy of Sciences 102 (35), 12350-12355, 2005	203	2005
Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein AI Nash, R McNulty, ME Shillito, TE Swartz, RA Bogomolni, H Luecke, ... Proceedings of the National Academy of Sciences 108 (23), 9449-9454, 2011	197	2011

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