| Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 HM Ismail, V Barton, M Phanchana, S Charoensutthivarakul, MHL Wong, ... Proceedings of the National Academy of Sciences 113 (8), 2080-2085, 2016 | 276 | 2016 |
| Antimalarial pharmacology and therapeutics of atovaquone GL Nixon, DM Moss, AE Shone, DG Lalloo, N Fisher, PM O'Neill, SA Ward, ... Journal of Antimicrobial Chemotherapy 68 (5), 977-985, 2013 | 200 | 2013 |
| Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria GA Biagini, N Fisher, AE Shone, MA Mubaraki, A Srivastava, A Hill, ... Proceedings of the National Academy of Sciences 109 (21), 8298-8303, 2012 | 192 | 2012 |
| Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs PA Stocks, PG Bray, VE Barton, M Al-Helal, M Jones, NC Araujo, ... Angewandte Chemie-International Edition 46 (33), 6278-6283, 2007 | 168 | 2007 |
| Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria GA Biagini, P Viriyavejakul, PM O'neill, PG Bray, SA Ward Antimicrobial agents and chemotherapy 50 (5), 1841-1851, 2006 | 168 | 2006 |
| Prioritization of anti‐SARS‐Cov‐2 drug repurposing opportunities based on plasma and target site concentrations derived from their established human pharmacokinetics U Arshad, H Pertinez, H Box, L Tatham, RKR Rajoli, P Curley, M Neary, ... Clinical Pharmacology & Therapeutics 108 (4), 775-790, 2020 | 154 | 2020 |
| Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential T Antoine, N Fisher, R Amewu, PM O'Neill, SA Ward, GA Biagini Journal of antimicrobial chemotherapy 69 (4), 1005-1016, 2014 | 148 | 2014 |
| Inhibiting Plasmodium cytochrome bc1: a complex issue V Barton, N Fisher, GA Biagini, SA Ward, PM O’Neill Current opinion in chemical biology 14 (4), 440-446, 2010 | 144 | 2010 |
| A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs PM O'Neill, SA Ward, NG Berry, JP Jeyadevan, GA Biagini, E Asadollaly, ... Current topics in medicinal chemistry 6 (5), 479-507, 2006 | 138 | 2006 |
| Antimalarial chemotherapy: young guns or back to the future? GA Biagini, PM O'Neill, A Nzila, SA Ward, PG Bray Trends in parasitology 19 (11), 479-487, 2003 | 133 | 2003 |
| Antimalarial activity of primaquine operates via a two-step biochemical relay G Camarda, P Jirawatcharadech, RS Priestley, A Saif, S March, ... Nature communications 10 (1), 3226, 2019 | 129 | 2019 |
| PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX PG Bray, M Mungthin, IM Hastings, GA Biagini, DK Saidu, V Lakshmanan, ... Molecular microbiology 62 (1), 238-251, 2006 | 129 | 2006 |
| Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) C Pidathala, R Amewu, B Pacorel, GL Nixon, P Gibbons, WD Hong, ... Journal of medicinal chemistry 55 (5), 1831-1843, 2012 | 128 | 2012 |
| Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 MJ Capper, PM O’Neill, N Fisher, RW Strange, D Moss, SA Ward, ... Proceedings of the National Academy of Sciences 112 (3), 755-760, 2015 | 123 | 2015 |
| Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex GA Biagini, N Fisher, N Berry, PA Stocks, B Meunier, DP Williams, ... Molecular Pharmacology 73 (5), 1347-1355, 2008 | 122 | 2008 |
| Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression N Fisher, R Abd Majid, T Antoine, M Al-Helal, AJ Warman, DJ Johnson, ... Journal of Biological Chemistry 287 (13), 9731-9741, 2012 | 112 | 2012 |
| The malaria parasite type II NADH: quinone oxidoreductase: an alternative enzyme for an alternative lifestyle N Fisher, PG Bray, SA Ward, GA Biagini Trends in parasitology 23 (7), 305-310, 2007 | 107 | 2007 |
| Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs GA Biagini, EM Pasini, R Hughes, HP De Koning, HJ Vial, PM O'Neill, ... Blood 104 (10), 3372-3377, 2004 | 104 | 2004 |
| Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century PM O’Neill, BK Park, AE Shone, JL Maggs, P Roberts, PA Stocks, ... Journal of medicinal chemistry 52 (5), 1408-1415, 2009 | 102 | 2009 |
| The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store GA Biagini, PG Bray, DG Spiller, MRH White, SA Ward Journal of Biological Chemistry 278 (30), 27910-27915, 2003 | 101 | 2003 |
