Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β T Kawashima, A Kosaka, H Yan, Z Guo, R Uchiyama, R Fukui, D Kaneko, ... Immunity 38 (6), 1187-1197, 2013 | 231 | 2013 |
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses K Takahashi, T Shibata, S Akashi-Takamura, T Kiyokawa, Y Wakabayashi, ... The Journal of experimental medicine 204 (12), 2963-2976, 2007 | 228 | 2007 |
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking R Fukui, SI Saitoh, A Kanno, M Onji, T Shibata, A Ito, M Onji, M Matsumoto, ... Immunity 35 (1), 69-81, 2011 | 222 | 2011 |
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA-but against RNA-sensing R Fukui, S Saitoh, F Matsumoto, H Kozuka-Hata, M Oyama, K Tabeta, ... Journal of Experimental Medicine 206 (6), 1339-1350, 2009 | 214 | 2009 |
Cathepsins are required for Toll-like receptor 9 responses F Matsumoto, S Saitoh, R Fukui, T Kobayashi, N Tanimura, K Konno, ... Biochemical and biophysical research communications 367 (3), 693-699, 2008 | 190 | 2008 |
DNase II-dependent DNA digestion is required for DNA sensing by TLR9 MP Chan, M Onji, R Fukui, K Kawane, T Shibata, S Saitoh, U Ohto, ... Nature communications 6 (1), 5853, 2015 | 126 | 2015 |
Guanosine and its modified derivatives are endogenous ligands for TLR7 T Shibata, U Ohto, S Nomura, K Kibata, Y Motoi, Y Zhang, Y Murakami, ... International immunology 28 (5), 211-222, 2016 | 113 | 2016 |
Mechanisms controlling nucleic acid-sensing Toll-like receptors K Miyake, T Shibata, U Ohto, T Shimizu, SI Saitoh, R Fukui, Y Murakami International immunology 30 (2), 43-51, 2018 | 95 | 2018 |
An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing M Onji, A Kanno, SI Saitoh, R Fukui, Y Motoi, T Shibata, F Matsumoto, ... Nature communications 4 (1), 1949, 2013 | 95 | 2013 |
Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis M Hirai, N Kadowaki, T Kitawaki, H Fujita, A Takaori-Kondo, R Fukui, ... Blood, The Journal of the American Society of Hematology 117 (2), 500-509, 2011 | 95 | 2011 |
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells SI Saitoh, F Abe, A Kanno, N Tanimura, Y Mori Saitoh, R Fukui, T Shibata, ... Nature communications 8 (1), 1592, 2017 | 93 | 2017 |
UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5 JW Huh, T Shibata, M Hwang, EH Kwon, MS Jang, R Fukui, A Kanno, ... Proceedings of the National Academy of Sciences 111 (19), 7072-7077, 2014 | 78 | 2014 |
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases A Kanno, N Tanimura, M Ishizaki, K Ohko, Y Motoi, M Onji, R Fukui, ... Nature communications 6 (1), 6119, 2015 | 77 | 2015 |
Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis R Sato, A Kato, T Chimura, SI Saitoh, T Shibata, Y Murakami, R Fukui, ... Nature immunology 19 (10), 1071-1082, 2018 | 63 | 2018 |
Selectivity of human TLR9 for double CpG motifs and implications for the recognition of genomic DNA J Pohar, C Yamamoto, R Fukui, MM Cajnko, K Miyake, R Jerala, ... The Journal of Immunology 198 (5), 2093-2104, 2017 | 55 | 2017 |
Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing Y Murakami, R Fukui, Y Motoi, A Kanno, T Shibata, N Tanimura, S Saitoh, ... The Journal of Immunology 193 (10), 5208-5217, 2014 | 55 | 2014 |
Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing A Kanno, C Yamamoto, M Onji, R Fukui, S Saitoh, Y Motoi, T Shibata, ... International immunology 25 (7), 413-422, 2013 | 51 | 2013 |
Species-specific minimal sequence motif for oligodeoxyribonucleotides activating mouse TLR9 J Pohar, D Lainšček, R Fukui, C Yamamoto, K Miyake, R Jerala, ... The Journal of Immunology 195 (9), 4396-4405, 2015 | 48 | 2015 |
Anti-TLR7 antibody protects against lupus nephritis in NZBWF1 mice by targeting B cells and patrolling monocytes Y Murakami, R Fukui, R Tanaka, Y Motoi, A Kanno, R Sato, K Yamaguchi, ... Frontiers in Immunology 12, 777197, 2021 | 29 | 2021 |
The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA Y Murakami, R Fukui, Y Motoi, T Shibata, SI Saitoh, R Sato, K Miyake Scientific Reports 7 (1), 44042, 2017 | 26 | 2017 |